S1194
SB-258585 二盐酸盐
≥98% (HPLC), powder
别名:
4-Iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H22N3O3SI · 2HCl
分子量:
560.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
SB-258585 二盐酸盐, ≥98% (HPLC), powder
InChI
1S/C18H22IN3O3S.2ClH/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16;;/h3-8,13,20H,9-12H2,1-2H3;2*1H
SMILES string
Cl[H].Cl[H].COc1ccc(NS(=O)(=O)c2ccc(I)cc2)cc1N3CCN(C)CC3
InChI key
QDYGVTFRTVLFCD-UHFFFAOYSA-N
description
Store under nitrogen; package with desiccants at 4°C
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
originator
GlaxoSmithKline
storage temp.
2-8°C
Quality Level
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Biochem/physiol Actions
5-HT6 serotonin receptor antagonist.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
W D Hirst et al.
British journal of pharmacology, 130(7), 1597-1605 (2000-08-06)
SB-258585 (4-Iodo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzen esulphonamide) is a high affinity ligand at 5-HT(6) receptors. It displays over 100 fold selectivity for the 5-HT(6) receptor over all other 5-HT receptors tested so far. SB-258585 has been radiolabelled, to high specific activity, for its characterization
C Routledge et al.
British journal of pharmacology, 130(7), 1606-1612 (2000-08-06)
SB-271046, potently displaced [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT(6) receptors recombinantly expressed in HeLa cells in vitro (pK(i) 8.92 and 9.09 respectively). SB-271046 also displaced [(125)I]-SB-258585 from human caudate putamen and rat and pig striatum membranes (pK(i) 8.81, 9.02 and
Jennifer C Roberts et al.
Brain research, 934(1), 49-57 (2002-04-09)
We used the highly selective 5-HT(6) receptor radioligand [(125)I]SB-258585 (4-iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide) to perform autoradiographic binding studies on the rat brain. High levels of specific binding occurred in the corpus striatum, nucleus accumbens, Islands of Calleja and the olfactory tubercle. A high
Wei Zhang et al.
Scientific reports, 8(1), 15753-15753 (2018-10-27)
Epidemiological observations have shown that schizophrenia patients after long-term drug treatment exhibited reduced tumor incidences. The potential anticancer effects of antipsychotic drugs are subsequently demonstrated. These drugs are of great interest as agents against untreatable brain metastases because of their
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