S1194
SB-258585 二盐酸盐
≥98% (HPLC), powder
别名:
4-Iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide
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关于此项目
经验公式（希尔记法）:
C18H22N3O3SI · 2HCl
分子量:
560.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
description
Store under nitrogen; package with desiccants at 4°C
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].COc1ccc(NS(=O)(=O)c2ccc(I)cc2)cc1N3CCN(C)CC3
InChI
1S/C18H22IN3O3S.2ClH/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16;;/h3-8,13,20H,9-12H2,1-2H3;2*1H
InChI key
QDYGVTFRTVLFCD-UHFFFAOYSA-N
Biochem/physiol Actions
5-HT6 serotonin receptor antagonist.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
W D Hirst et al.
British journal of pharmacology, 130(7), 1597-1605 (2000-08-06)
SB-258585 (4-Iodo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzen esulphonamide) is a high affinity ligand at 5-HT(6) receptors. It displays over 100 fold selectivity for the 5-HT(6) receptor over all other 5-HT receptors tested so far. SB-258585 has been radiolabelled, to high specific activity, for its characterization
Jennifer C Roberts et al.
Brain research, 934(1), 49-57 (2002-04-09)
We used the highly selective 5-HT(6) receptor radioligand [(125)I]SB-258585 (4-iodo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzene-sulfonamide) to perform autoradiographic binding studies on the rat brain. High levels of specific binding occurred in the corpus striatum, nucleus accumbens, Islands of Calleja and the olfactory tubercle. A high
C Routledge et al.
British journal of pharmacology, 130(7), 1606-1612 (2000-08-06)
SB-271046, potently displaced [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT(6) receptors recombinantly expressed in HeLa cells in vitro (pK(i) 8.92 and 9.09 respectively). SB-271046 also displaced [(125)I]-SB-258585 from human caudate putamen and rat and pig striatum membranes (pK(i) 8.81, 9.02 and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S1194-10MG | 04061832084541 |
| S1194-50MG | 04061832084558 |