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S1195

ST638

Name: ST638
Brand: SIGMA

≥98% (HPLC), solid

别名:

α-Cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide

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关于此项目

经验公式（希尔记法）:

C₁₉H₁₈N₂O₃S

化学文摘社编号:

107761-24-0

分子量:

354.42

NACRES:

NA.77

PubChem Substance ID:

329824465

UNSPSC Code:

12352200

MDL number:

MFCD00236446

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

yellow

mp

134-135.5 °C

solubility

DMSO: 19 mg/mL

storage temp.

−20°C

SMILES string

CCOc1cc(cc(CSc2ccccc2)c1O)\C=C(/C#N)C(N)=O

InChI

1S/C19H18N2O3S/c1-2-24-17-10-13(8-14(11-20)19(21)23)9-15(18(17)22)12-25-16-6-4-3-5-7-16/h3-10,22H,2,12H2,1H3,(H2,21,23)/b14-8+

InChI key

YKLMGKWXBLSKPK-RIYZIHGNSA-N

说明

Biochem/physiol Actions

Protein tyrosine kinase inhibitor (IC₅₀ = 370 nM). Also inhibits HGF-induced MAP kinase activation in hepatocytes and inhibits phospholipase D activity in human neutrophils.

Packaging

Light sensitive and packaged under nitrogen.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number

015K4609

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The effect of tyrosine kinase inhibitors on IgE-mediated histamine release from human lung mast cells and basophils.

S E Lavens-Phillips et al.

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 47(3), 137-143 (1998-04-30)

To investigate the role of tyrosine kinases (TK) in IgE-mediated signal transduction in human lung mast cells (HLMC) and basophils. Peripheral blood basophils (n > or = 4) and human lung mast cells (n > or = 6). Cells were

Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs.

Y Fukumoto et al.

Cardiovascular research, 32(6), 1131-1140 (1996-12-01)

Restenosis after percutaneous transluminal coronary angioplasty (PTCA) still remains a serious late complication. Many growth factors induced in restenotic lesions may be responsible for restenosis after PTCA. Most of the receptors for such growth factors possess tyrosine kinase activity. This

Activation of the macrophage respiratory burst by phorbol myristate acetate: evidence for both tyrosine-kinase-dependent and -independent pathways.

S P Green et al.

Biochimica et biophysica acta, 1222(2), 241-248 (1994-06-30)

We have investigated the relationship between tyrosine phosphorylation and respiratory-burst activity in murine bone-marrow-derived macrophages (BMM) stimulated with phorbol myristate acetate (PMA). In unprimed BMM, a good correlation was observed between the net level of tyrosine phosphorylation and the activity

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货号	GTIN
S1195-5MG	04061832962795