产品名称
Monoclonal Anti-SERCa2 ATPase antibody produced in mouse, clone 2A7-A1, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2A7-A1, monoclonal
mol wt
antigen 110 kDa
contains
0.05% sodium azide
species reactivity
guinea pig, human, canine, mouse, rat, rabbit
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ATP2A2(488)
mouse ... Atp2a2(11938)
rat ... Atp2a2(29693)
Application
Anti-SERCa2 ATPase antibody has been used in western blotting and immunocytochemistry.
Biochem/physiol Actions
Mutation of SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) or ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) causes Dyskeratosis follicularis. SERCA2a plays a major role in controlling cardiomyocyte Ca2+. ATP2A2 mutation may cause Darier disease (DD).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) is also known as ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). It codes for SERCA2a and SERCA2b, that are expressed in all tissues. SERCA2a is highly expressed in heart. SERCa2 is located on human chromosome 12q24.1.
Immunogen
canine cardiac sarcoplasmic reticulum vesicles
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动植物来源生物产品
此项目有
Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes
Revuelta-Lopez E, et al.
Journal of Molecular and Cellular Cardiology, 85, 25-36 (2015)
Clinical case of acral hemorrhagic Darier's disease is not caused by mutations in exon 15 of the ATP2A2 gene
Pecina-Slaus N, et al.
Collegium Antropologicum, 27(1), 125-133 (2003)
Modulation of sarcoplasmic reticulum Ca(2+)-ATPase by chronic and acute exposure to peroxynitrite
Gutierrez-Martin Y, et al.
European Journal of Biochemistry, 271(13), 2647-2657 (2004)
[Analysis of ATP2A2 gene mutations in a pedigree and a sporadic case with Darier disease]
Zhao X, et al.
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 33(5), 641-644 (2016)
Humberto Muzi-Filho et al.
Physiological reports, 3(10) (2015-10-29)
Epidemiological and animal studies have shown that placental undernutrition impairs reproduction in adult offspring, but the underlying molecular mechanisms within the male genital tract remain unknown. Due to its special physiological characteristics in transport and the modulation of the environment
相关内容
Datasheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持