S1442
Sordarin sodium salt 钠盐
From Sordaria araneosa, ≥98% (HPLC), eukaryotic protein synthesis inhibitor, solid
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经验公式（希尔记法）:
C27H39NaO8
化学文摘社编号:
分子量:
514.58
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Sordarin sodium salt 钠盐, from Sordaria araneosa, ≥98% (HPLC), solid
SMILES string
[Na+].[H]C(=O)[C@]12C[C@]3([H])C=C(C(C)C)[C@@]1(C([O-])=O)[C@]3(CO[C@@H]4O[C@H](C)[C@@H](OC)[C@@H](O)[C@@H]4O)C[C@]5([H])[C@H](C)CC[C@@]25[H]
InChI key
ILUKWKGTAAZHDW-IGICPMPSSA-M
InChI
1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23;/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32);/q;+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+;/m1./s1
biological source
Sordaria araneosa
assay
≥98% (HPLC)
form
solid
solubility
H2O: soluble ≤10 mg/mL
antibiotic activity spectrum
fungi
mode of action
protein synthesis | interferes
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
Soradrin sodium salt has been used as an antifungal compound to treat mycelia for immunofluorescence microscopy studies. It may be used in in vitro diphtheria toxin sensitivity assays.
Biochem/physiol Actions
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin.
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Wael Abdel-Fattah et al.
Toxins, 5(5), 958-968 (2013-05-07)
Diphtheria toxin (DT) inhibits eukaryotic translation elongation factor 2 (eEF2) by ADP-ribosylation in a fashion that requires diphthamide, a modified histidine residue on eEF2. In budding yeast, diphthamide formation involves seven genes, DPH1-DPH7. In an effort to further study diphthamide
Marta Cotado-Sampayo et al.
Fungal genetics and biology : FG & B, 45(6), 1008-1015 (2008-04-02)
Spectrin was first described in erythrocytes where it forms a filamentous network in the cytoplasmic face of the plasma membrane and participates in the membrane's structural integrity in addition to controlling the lateral mobility of integral membrane proteins. In fungi
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