S1451
Anti-Sox2 antibody, Mouse monoclonal
clone SOX2-6, purified from hybridoma cell culture
别名:
Anti-ANOP3, Anti-MCOPS3, Anti-SRY (sex determining region Y)-box 2, Anti-SRY-related HMG-box gene 2, Anti-Sex-determining region Y-box 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SOX2-6, monoclonal
Application:
WB
Citations:
12
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
SOX2-6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~35 kDa
species reactivity
human, mouse
concentration
~1.0 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using whole extract of human NT2 cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SOX2(6657)
mouse ... Sox2(20674)
rat ... Sox2(499593)
General description
Monoclonal Anti-SOX2 (mouse IgG1 isotype) is derived from the hybridoma SOX2-6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SOX2 (sex-determining region Y-box 2) is a transcription factor that is made of 317 amino acid. It has a HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.
Application
Anti-Sox2 antibody has been used in western blotting and immunohistochemistry.
Biochem/physiol Actions
Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects the breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog
Nishii T, et al.
The Journal of Biological Chemistry, 287(15), 12417-12424 (2012)
Thais Fernanda de Almeida Galatro et al.
PloS one, 8(4), e61605-e61605 (2013-04-25)
Inhibitor of DNA Binding 4 (ID4) is a member of the helix-loop-helix ID family of transcription factors, mostly present in the central nervous system during embryonic development, that has been associated with TP53 mutation and activation of SOX2. Along with
CIBZ Regulates Mesodermal and Cardiac Differentiation of by Suppressing T and Mesp1 Expression in Mouse Embryonic Stem Cells
Kotoku T, et al.
Scientific Reports, 6 (2016)
Differential expression of ID4 and its association with TP53 mutation, SOX2, SOX4 and OCT-4 expression levels
Galatro TF, et al.
PLoS ONE, 8(4) (2013)
SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
Hussenet T, et al.
PLoS ONE, 5(1) (2010)
商品
Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation.
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