S1563
SKF-86466 hydrochloride
solid, ≥98% (HPLC)
别名:
6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
H2O: 24 mg/mL
SMILES字符串
Cl.CN1CCc2cccc(Cl)c2CC1
InChI
1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H
InChI key
JKQKVNMNAIFCFS-UHFFFAOYSA-N
基因信息
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
应用
SKF 86466 was used to study adrenoceptor signaling in rat limbic seizure models.
生化/生理作用
SKF 86466 binds specifically to α2-adrenoceptors at pre- and post-junctional sites but was also reported to antagonize α1-aderenoceptors in humans. The structural similarity of receptors enables SKF 86466 binding to 5-HT1A receptors.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
M S Hedrick et al.
Respiration physiology, 101(2), 129-137 (1995-08-01)
The purpose of this study was to test the hypothesis that respiratory and apneas induced by alpha 2 agonists in anesthetized goats are associated with an increase of upper airway expiratory-related activity, rather than a general depression of breathing. Activities
Ralph Clinckers et al.
Journal of neurochemistry, 115(6), 1595-1607 (2010-10-26)
Noradrenaline exerts inhibitory effects on seizure susceptibility. Subtype selective agonists and antagonists were used to identify the anticonvulsant hippocampal adrenoreceptors. Intrahippocampal dialysis was used for administration of all compounds, including pilocarpine for limbic seizure induction, and as the neurotransmitter sampling
M A Haxhiu et al.
Advances in experimental medicine and biology, 454, 467-473 (1999-01-16)
In these studies we determined the effects of local hypoxia confined to the superficial structures of the ventral medulla on cholinergic outflow to the airways. Studies were performed in alpha-chloralose anesthetized, paralyzed and mechanically ventilated cats. Topical application or microinjection
S Sesoko et al.
The American journal of physiology, 274(4 Pt 2), R1119-R1124 (1998-05-12)
The inhibitory action of alpha 2-agonists on the cardiovascular neurons has been elucidated in the rostral ventrolateral medulla (RVLM) but not in the caudal ventrolateral medulla (CVLM). Our study aimed to clarify whether microinjection of clonidine into the CVLM elicits
Ellen W King et al.
Pain, 115(3), 364-373 (2005-05-25)
The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine. These receptors also produce antinociceptive synergy when activated concurrently with opioid receptor activation. The involvement of the opioid receptors in the mechanisms governing
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