S166
Saclofen
solid
别名:
β-（氨甲基）-4-氯苯乙磺酸
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关于此项目
经验公式（希尔记法）:
C9H12ClNO3S
化学文摘社编号:
分子量:
249.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Form:
solid
Quality level:
产品名称
Saclofen, solid
InChI key
JYLNVJYYQQXNEK-UHFFFAOYSA-N
SMILES string
NCC(CS(O)(=O)=O)c1ccc(Cl)cc1
InChI
1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
form
solid
color
white
solubility
0.1 M NaOH: 20 mg/mL
Quality Level
Gene Information
human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)
Application
Saclofen已被用于阻止催产素对辣椒素诱导的谷氨酸自发兴奋性传递的抑制作用。
使用Saclofen作为GABAB受体拮抗剂以研究大鼠反复注射羟考酮的镇痛作用。
Biochem/physiol Actions
Saclofen可能具有交感神经系统依赖性抗炎作用。
Saclofen是巴氯芬的磺酸类似物，是一种选择性GABAB受体拮抗剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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