S1689
Monoclonal Anti-Sarcalumenin antibody produced in mouse
clone XIIC4, purified immunoglobulin
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关于此项目
Conjugate:
unconjugated
Clone:
XIIC4, monoclonal
Application:
IF, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
XIIC4, monoclonal
mol wt
antigen 53 kDa
species reactivity
mouse, rabbit, canine, guinea pig
technique(s)
indirect immunofluorescence: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Srl(106393)
General description
Sarcalumenin (SAR) is a Ca2+ binding protein. It is present in the longitudinal sarcoplasmic reticulum. It is expressed in the striated muscle cells.
Immunogen
purified rabbit sarcoplasmic reticulum membrane vesicles.
Biochem/physiol Actions
In mice, deletion of sarcalumenin increases resistance to fatigue and altered calcium handling properties. It is required in the maintenance of cardiac activities throughout endurance exercise training. It modulates the reuptake of Ca2+ into the sarcoplasmic reticulum. It also plays an important role in age-related cardiac malfunction.
Physical form
Solution in phosphate buffered saline containing 0.05% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice
Yoshida M, et al.
The Journal of Biological Chemistry, 280(5), 3500-3506 (2005)
Sarcalumenin is essential for maintaining cardiac function during endurance exercise training
Jiao Q, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 297(2), H576-H582 (2009)
Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice
Zhao X, et al.
Physiological Genomics, 23(1), 72-78 (2005)
Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity
Jiao Q, et al.
Cell Calcium, 51(1), 31-39 (2012)
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