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Merck
CN

S1820

Ser-Phe-Leu-Leu-Arg-Asn-酰胺 三氟乙酸盐

≥98% (HPLC), Thrombin receptor activating peptide, lyophilized powder

别名:

PAR-1(蛋白酶激活受体)选择性激活肽, PAR1-AP, SFLLRN-NH2

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关于此项目

线性分子式:
C34H57N11O8 · x CF3COOH
化学文摘社编号:
分子量:
747.89 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
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产品名称

Ser-Phe-Leu-Leu-Arg-Asn-酰胺 三氟乙酸盐, ≥98% (HPLC), lyophilized powder

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O

InChI key

YICKZNIVMKPQPD-POCCEKOUSA-N

InChI

1S/C34H57N11O8.C2HF3O2/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20;3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40);(H,6,7)/t21-,22-,23-,24-,25-,26-;/m0./s1

assay

≥98% (HPLC)

form

lyophilized powder

color

white

UniProt accession no.

storage temp.

−20°C

Quality Level

Gene Information

human ... IGF1R(3480)

Application

Ser-Phe-Leu-Leu-Arg-Asn-酰胺三氟乙酸盐可作为蛋白酶激活受体1(PAR-1)特异性激动剂肽。

Biochem/physiol Actions

Ser-Phe-Leu-Leu-Arg-Asn-酰胺三氟乙酸盐(SFLLRN)可作为蛋白酶激活受体1(PAR-1)特异性激动剂肽。
凝血酶受体激活肽(TRAP)。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Thrombin induces Ca2+-dependent glutamate release from RPE cells mediated by PLC/PKC and reverse Na+/Ca2+ exchange
Lopez E, et al.
Molecular Vision (2019)
J. S. Davies
Amino Acids, Peptides and Proteins, 29 (1998)
Nicola Maggio et al.
Hippocampus, 24(8), 1030-1038 (2014-04-23)
Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either
Visualizing dynamics of cell signaling in vivo with a phase separation-based kinase reporter
Zhang Q, et al.
Molecular Cell, 69(2), 334-346 (2018)
B Batman et al.
Vox sanguinis, 112(8), 773-779 (2017-09-30)
Prophylactic platelet transfusions are administered to prevent bleeding in haemato-oncological patients. However, bleeding still occurs, despite these transfusions. This practice is costly and not without risk. Better predictors of bleeding are needed, and flow cytometric evaluation of platelet function might

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