S2075
Src抑制剂-1
≥98% (HPLC), Src kinase inhibitor, powder
别名:
4-(4′-苯氧基苯胺)-6,7-二甲氧基喹唑啉, 6,7-二甲氧基-N-（4-苯氧基苯基）-4-喹唑啉, SKI-1, Src-l1
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关于此项目
经验公式（希尔记法）:
C22H19N3O3
化学文摘社编号:
分子量:
373.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Src抑制剂-1, ≥98% (HPLC)
SMILES string
COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
InChI key
DMWVGXGXHPOEPT-UHFFFAOYSA-N
InChI
1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Application
Src抑制剂-1可用于Src激酶介导的细胞信号转导研究。
Biochem/physiol Actions
Src抑制剂-1是一种有效的、竞争性的双重位点（ATP和肽结合）Src激酶抑制剂。
Src抑制剂-1是一种有效的、竞争性的双重位点（ATP和肽结合）Src激酶抑制剂。Src抑制剂-1是Src激酶抑制的“金标准”之一。研究已经显示通过Src-I1与PP1或PP2一起使用可抑制Src家族激酶。Src抑制剂-1是酪氨酸激酶Src家族的选择性竞争性抑制剂（分别对于Src和Lck的IC50为44nM和88nM）。Src抑制剂-1可以更高的浓度抑制VEGFR2和c-fms酪氨酸激酶（IC50分别为0.32 μM和30 μM）。
除Src激酶外，一些Src抑制剂也可抑制Abl激酶、Lck、Csk和Yes蛋白的活性，因此研究人员正在探索将其作为可行的抗癌药物的可能性。
Features and Benefits
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
Diane H Boschelli et al.
Journal of medicinal chemistry, 47(7), 1599-1601 (2004-03-19)
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.
Lei Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 57, 72-83 (2019-01-23)
Periploca forrestii(PF) is mainly utilized for treatment of arthritis and traumatic injury historically. We had previously demonstrated that a fraction rich in cardiotonic steroids isolated from PF had the potential to facilitate wound healing. However, the exact material basis and
Klaske M Schukken et al.
Life science alliance, 3(2) (2020-01-26)
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify
Devin McGee et al.
PloS one, 12(11), e0188645-e0188645 (2017-12-01)
Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using
Scott T Wood et al.
Arthritis & rheumatology (Hoboken, N.J.), 68(1), 117-126 (2015-09-01)
Oxidative posttranslational modifications of intracellular proteins can potentially regulate signaling pathways relevant to cartilage destruction in arthritis. In this study, oxidation of cysteine residues to form sulfenic acid (S-sulfenylation) was examined in osteoarthritic (OA) chondrocytes and investigated in normal chondrocytes
商品
Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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