生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 23 kDa
种属反应性
mouse
技术
indirect immunofluorescence: 1:200 using mouse embryonic 3T3-L1 cell line
western blot: 1:1,000 using whole cell extract of mouse fibroblasts NIH3T3 cell line
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SNAP23(8773)
mouse ... Snap23(20619)
rat ... Snap23(64630)
一般描述
Synaptosomal-associated protein, 23 kDa, syndet (SNAP23), belonging to the SNAP25 family genes is a non-neuronal isoform of synaptosomal-associated protein 25 (SNAP-25), originally identified in a human B-lymphocyte cDNA library in a yeast two-hybrid screen for proteins interacting with syntaxin 4. SNAP-23 is ubiquitously expressed and is localized mainly to the plasma membrane. The primary structure of SNAP-23 is 59% identical to SNAP-25. It contains a central cluster of cysteine residues and predicted coiled-coil segments. It is a tSNARE which has two tandem soluble N-ethylmale-imide-sensitive factor-attachment protein receptor (SNARE) motifs. SNAP23 gene has eight exons and is located on human chromosome 15q21−22.
特异性
Anti-SNAP-23 (DS-19) recognizes SNAP-23 (23 kDa).
免疫原
synthetic peptide corresponding to amino acids 2-20 of mouse SNAP-23, conjugated to KLH.This sequence is highly conserved in rat (90% identity) and human (78% identity) SNAP-23.
应用
Anti-SNAP-23 (DS-19) antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
生化/生理作用
Synaptosomal-associated protein, 23 kDa, syndet (SNAP23) plays a vital role in various protein trafficking events in non-neuronal cells. It is mainly involved in polarized protein trafficking, glucose transporter type 4 (GLUT4) trafficking in adipocytes, compound exocytosis in mast cells and platelet dense core granule release. This gene acts as an oncogene in ovarian cancer (OC). This gene is capable of producing two forms of message, such as the full length message (SNAP23A) and a shorter message (SNAP23B).
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
储存及稳定性
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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