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文件

S2628

N-琥珀酰- L -苯丙氨酸- p -硝基苯胺

Name: N-琥珀酰-<SC> L </SC>-苯丙氨酸-<I> p </I>-硝基苯胺
Brand: SIGMA

protease substrate

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别名:

Suc-Phe-pNA

经验公式（希尔记法）:

C₁₉H₁₉N₃O₆

CAS号:

2440-62-2

分子量:

385.37

EC 号:

219-472-6

MDL编号:

MFCD00047721

PubChem化学物质编号:

24899530

NACRES:

NA.32

质量水平

200

检测方案

≥98% (TLC)

形式

powder

溶解性

dioxane: 25 mg/mL, clear, colorless to faintly yellow

储存温度

−20°C

SMILES string

OC(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc2ccc(cc2)N(=O)=O

InChI

1S/C19H19N3O6/c23-17(10-11-18(24)25)21-16(12-13-4-2-1-3-5-13)19(26)20-14-6-8-15(9-7-14)22(27)28/h1-9,16H,10-12H2,(H,20,26)(H,21,23)(H,24,25)/t16-/m0/s1

InChI key

KNBLWBFJHZHYFG-INIZCTEOSA-N

应用

N -琥珀酰- L -苯丙氨酸- p -硝基苯胺已被用作糜蛋白酶水解活性的底物和摩尔吸光实验。也用于体外监测 α-糜蛋白酶抑制试验。

生化/生理作用

糜蛋白酶水解活性的底物 N -琥珀酰- L -苯丙氨酸- p -硝基苯胺形成黄色生色团 p -硝基苯胺，可在 410 nm 处分光光度法测定。

底物

据报道，这是一种糜蛋白酶的底物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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T1503

货号

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[Solid-phase enzymatic reactions. V. Comparison of catalytic properties of subtilisin and alpha-chymotrypsin in the absence of a solvent].

E Iu Maksareva et al.

Bioorganicheskaia khimiia, 21(1), 24-27 (1995-01-01)

Subtilisin Carlsberg (E.C. 3.4.21.14) catalyzes the hydrolysis of N-succinyl-L-phenylalanine p-nitroanilide in solid-state solvent-free hydrated protein-substrate mixtures. This process needs a certain critical degree of hydration of the protein molecule which is attained at the relative water vapour pressure (p/ps) above

Effect of crowding by dextrans on the hydrolysis of N-Succinyl-L-phenyl-Ala-p-nitroanilide catalyzed by α-chymotrypsin.

Isabel Pastor et al.

The journal of physical chemistry. B, 115(5), 1115-1121 (2010-12-31)

Traditionally, studies on the diffusion-controlled reaction of biological macromolecules have been carried out in dilute solutions (in vitro). However, in an intracellular environment (in vivo), there is a high concentration of macromolecules, which results in nonspecific interactions (macromolecular crowding). This

Pressure effects on enzyme reactions in mainly organic media: alpha-chymotrypsin in reversed micelles of Aerosol OT in octane.

V V Mozhaev et al.

Biochemistry and molecular biology international, 34(1), 191-199 (1994-08-01)

Biocatalytic transformations in reversed micelles formed by anionic surfactant Aerosol OT in octane have been studied at high pressures by an example of alpha-chymotrypsin-catalyzed hydrolysis of N-carbobenzoxy-L-tyrosine p-nitrophenyl ester and N-succinyl-L-phenylalanine p-nitroanilide. For the first time it has been found

Mercury (II) binds to both of chymotrypsin's histidines, causing inhibition followed by irreversible denaturation/aggregation

Stratton A, et al.

Protein Science, 26(2), 292-305 (2017)

Cyclopeptide alkaloids of Ziziphus oxyphylla Edgw as novel inhibitors of alpha-glucosidase enzyme and protein glycation

Choudhary MI, et al.

Phytochemistry Letters, 4(4), 404-406 (2011)

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