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S2694

SB-408124

Name: SB-408124
Brand: SIGMA

≥98% (HPLC), solid

别名:

N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N′-[4-(dimethylamino)phenyl]urea

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关于此项目

经验公式（希尔记法）:

C₁₉H₁₈F₂N₄O

化学文摘社编号:

288150-92-5

分子量:

356.37

NACRES:

NA.77

PubChem Substance ID:

329824523

UNSPSC Code:

51111800

MDL number:

MFCD06411575

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >10 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(NC(=O)Nc2cc(C)nc3c(F)cc(F)cc23)cc1

InChI

1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26)

InChI key

JTARFZSNUAGHRB-UHFFFAOYSA-N

说明

Application

SB-408124 was used to block orexin A-mediated cardiovascular effects in rats.It was used to study block the increase of endogenous glucose production mediated by bicuculline in rats.

Biochem/physiol Actions

SB 408124 is an OX₁ orexin receptor antagonist.

SB-408124 blocks the orexin type 1 receptor that stimulates the production of stress hormone in hypothalamus. It blocks orexin A-induced increase in arterial pressure and elevation of heart rate in rats. SB-408124 modulates phrenic nerve activity that is important in respiration.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress.

Willis K Samson et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 292(1), R382-R387 (2006-08-12)

Hypocretin/orexin acts pharmacologically in the hypothalamus to stimulate stress hormone secretion at least in part by an action in the hypothalamic paraventricular nucleus, where the peptide's receptors have been localized. In addition, orexin acts in the brain to increase sympathetic

Modulation of respiratory activity by hypocretin-1 (orexin A) in situ and in vitro.

Andrea Corcoran et al.

Advances in experimental medicine and biology, 669, 109-113 (2010-03-11)

Release of hypocretins (orexins) by neurons in the lateral hypothalamus is an important contributor to arousal state, thermoregulation, feeding behavior, and has recently been proposed to play a role in breathing and central chemosensitivity. Using the in situ arterially perfused

CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.

Kaiyu Xu et al.

Nature communications, 11(1), 3594-3594 (2020-07-19)

Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA isoform derived from the genomic loci of α-mino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit Gria1, shows an age-related and

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全球贸易项目编号

货号	GTIN
S2694-25MG	04061832867809
S2694-5MG	04061832867816