S3065
SC 19220
≥98% (HPLC), solid
别名:
2-乙酰肼 10 (11H)-羧酸, 8-氯代二苯 [b,f] [1,4] 恶嗪-10 (11H)-羧酸
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关于此项目
经验公式（希尔记法）:
C16H14N3O3Cl
CAS Number:
分子量:
331.75
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
mp
190-191 °C (lit.)
溶解性
DMSO: soluble 10 mg/mL
H2O: insoluble
SMILES字符串
CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13
InChI
1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
InChI key
KNURFLJTOUGOOQ-UHFFFAOYSA-N
基因信息
human ... PTGER1(5731)
rat ... Ptger1(25637)
应用
采用 SC 19220 研究前列腺素 E 2 在大鼠皮质培养物中氧糖剥夺诱导的神经毒性和预处理诱导的神经保护中的作用。
生化/生理作用
EP 1 前列腺素受体拮抗剂
SC 19220 是前列腺素 E 受体的竞争性拮抗剂。它与 PGE 2 竞争调节膀胱尿道运动，并增加大鼠膀胱容量。它能抑制平滑肌对前列腺素 E 2 和 F 2α 的收缩反应。SC 19220 还可抑制维生素 D3、甲状旁腺激素、IL-11 和 IL-6 诱导的破骨细胞的形成。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
H Inoue et al.
The Journal of endocrinology, 161(2), 231-236 (1999-05-13)
1,25 Dihydroxy vitamin D3 (1,25(OH)2D3), prostaglandin (PG) E2 and parathyroid hormone (PTH) induce osteoclast formation in cell cultures. Previously, we have shown that SC-19220, an antagonist of the EP1 subtype of PGE receptors, inhibited tartrate-resistant acid phosphatase (TRAP)-positive cell formation
Xavier Norel et al.
British journal of pharmacology, 142(4), 788-796 (2004-06-03)
1. In human pulmonary vascular preparations, precontracted arteries were more sensitive to the relaxant effect of acetylcholine (ACh) than veins (pD(2) values: 7.25+/-0.08 (n=23) and 5.92+/-0.09 (n=25), respectively). Therefore, the role of prostacyclin (PGI(2)) was explored to examine whether this
Alexander V Timoshenko et al.
Experimental cell research, 289(2), 265-274 (2003-09-23)
Aberrant upregulation of COX-2 enzyme resulting in accumulation of PGE2 in a cancer cell environment is a marker for progression of many cancers, including breast cancer. Four subtypes of cell surface receptors (EP1, EP2, EP3, and EP4), which are coupled
C A Maggi et al.
European journal of pharmacology, 152(3), 273-279 (1988-08-02)
SC-19220 (5-20 mg/kg i.v.), a competitive receptor antagonist of PGE, increased the bladder capacity and reduced the voiding efficiency of micturition (elicited by slow transvesical filling) of urethane-anesthetized rats. The effect of SC-19220 was prevented by indomethacin pretreatment, whereas indomethacin
F Del Toro et al.
Journal of cellular physiology, 182(2), 196-208 (2000-01-07)
Resting zone chondrocyte differentiation is modulated by the vitamin D metabolite, 24,25-(OH)(2)D(3), via activation of protein kinase C (PKC). In previous studies, inhibition of prostaglandin production with indomethacin caused an increase in PKC activity, suggesting that changes in prostaglandin levels
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