产品名称
螺内酯, 97.0-103.0%
Quality Segment
assay
97.0-103.0%
mp
207-208 °C (lit.)
solubility
chloroform: complete 50 mg/ml, clear, faintly yellow
SMILES string
CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13
InChI
1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
InChI key
LXMSZDCAJNLERA-ZHYRCANASA-N
Gene Information
human ... HSD17B1(3292), NR3C2(4306)
rat ... Ar(24208)
Application
Biochem/physiol Actions
Spironolactone reduces aldosterone-induced potassium/magnesium loss and myocardial fibrosis. It reduces hypertension, improves the endothelial function and reduces the overall morbidity and mortality in patients with chronic heart failure. Spironolactone improves nitric oxide bioactivity and vascular endothelial vasodilator dysfunction.
螺内酯是竞争性醛固酮受体拮抗剂。 用作保钾利尿剂。
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Spironolactone yields clear, faint yellow solution in chloroform at 50 mg/ml.
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警示词
Danger
危险代码
Hazard Classifications
Carc. 2 - Repr. 1B - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
怎么回事?
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE(个人防护设备)
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
