Merck
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文件

S3567

Sigma-Aldrich

SB 415286

≥98% (HPLC)

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别名:
3-[(3-Chloro-4-hydroxyphenyl)­amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
经验公式（希尔记法）:
C16H10N3O5Cl
CAS号:
264218-23-7
分子量:
359.72
MDL编号:
MFCD04039789
PubChem化学物质编号:
24278412

质量水平

100

检测方案

≥98% (HPLC)

颜色

yellow to orange

溶解性

DMSO: 5 mg/mL, clear
H2O: insoluble

创始人

GlaxoSmithKline

储存温度

−20°C

SMILES string

Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl

InChI

1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

InChI key

PQCXVIPXISBFPN-UHFFFAOYSA-N

Gene Information

human ... GSK3A(2931) , GSK3B(2932)

应用

SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

生化/生理作用

SB 415286 is a small molecule inhibitor of GSK-3 in muscle and fat cells. SB 415286 induces activation of glycogen synthase and regulates the transport glucose. SB 415286 reduces the systemic inflammation induced by endotoxic shock in rat model of acute colitis. It increases the axonal growth and promotes the recovery of injured adult CNS neurons. SB 415289 is implicated in inducing chromosome instability when used as therapeutic agents.
Glycogen synthase kinase-3 (GSK-3) inhibitor.

特点和优势

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from GlaxoSmithKline.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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John Dill et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(36), 8914-8928 (2008-09-05)
Axonal regeneration is minimal after CNS injuries in adult mammals and medical treatments to recover neurological deficits caused by axon disconnection are extremely limited. The failure of axonal elongation is principally attributed to the nonpermissive environment and reduced intrinsic growth
Jorge-Tonatiuh Ayala-Sumuano et al.
Scientific reports, 1, 178-178 (2012-02-23)
Adipogenesis is regulated by a complex cascade of transcriptional factors, but little is known about the early events that regulate the adipogenic program. Here, we report the role of the srebf1a gene in the differentiation of fibroblastic 3T3-F442A cells. We
Brendan J R Whittle et al.
British journal of pharmacology, 147(5), 575-582 (2005-11-30)
The effects of the inhibitors of glycogen synthase kinase-3beta (GSK-3beta), TDZD-8 and SB 415286, which can substantially reduce the systemic inflammation associated with endotoxic shock in vivo, have now been investigated on the acute colitis provoked by trinitrobenzene sulphonic acid
Hye Ree Yoon et al.
International journal of molecular sciences, 21(18) (2020-09-23)
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a protein kinase with diverse functions in cell regulation. Abnormal expression and activity of DYRK1A contribute to numerous human malignancies, Down syndrome, and Alzheimer's disease. Notably, DYRK1A has been proposed as a potential
Katrina MacAulay et al.
European journal of biochemistry, 270(18), 3829-3838 (2003-09-03)
Glycogen synthase kinase 3 (GSK3) is inactivated by insulin and lithium and, like insulin, Li also activates glycogen synthase (GS) via inhibition of GSK3. Li also mimics insulin's ability to stimulate glucose transport (GT), an observation that has led to
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