S3884
Sauvagine
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C202H346N56O63S
化学文摘社编号:
分子量:
4599.31
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
assay
≥97% (HPLC)
storage temp.
−20°C
InChI key
ILCVKEBXPLEGOY-ZLFMSJRASA-N
General description
Sauvagine is a polypeptide derived from the frog skin. It belongs to the CRH (corticotropin releasing factor) family. Sauvagine is made of 40 amino acids. It may also be found in the brain of mammals.
Biochem/physiol Actions
Sauvagine helps to liberate ACTH (adrenocorticotropic hormone) from the pituitary cells of rat. It has several important functions in the cardiovascular, endocrine and renal systems.
A peptide related to CRF and urotensin 1 that was first isolated from the skin of the frog Phyllomedusa sauvagei. Potent releaser of ACTH and β-endorphin from the anterior pituitary.
Other Notes
Lyophilized from 0.1% TFA in H2O
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
T Renda et al.
Archives of histology and cytology, 52 Suppl, 317-323 (1989-01-01)
The authors present an overview of the main amphibian peptide families mainly derived from the skin and mostly discovered by Erspamer and his associates. The studies of the peptides do not only promote the understanding of their chemical, metabolical and
Takeshi Nakamura et al.
American journal of physiology. Heart and circulatory physiology, 296(2), H325-H332 (2008-12-09)
Urocortin 3 (Ucn3) is a new member of the corticotropin-releasing factor (CRF) peptide family and is considered to be a specific and endogenous ligand for CRF type 2 receptors (CRF2Rs). The presence of CRF(2)Rs has been reported in the nucleus
Javier Santos et al.
Psychoneuroendocrinology, 33(9), 1248-1256 (2008-08-12)
Previously, we showed that corticotropin-releasing factor (CRF) injected i.p. mimicked epithelial responses to stress, both stimulating ion secretion and enhancing permeability in the rat colon, and mast cells were involved. However, the ability of CRF-sensitive mucosal/submucosal loops to regulate intestinal
Kostas Gkountelias et al.
Molecular pharmacology, 78(4), 785-793 (2010-07-29)
Family B of G protein-coupled receptors (GPCRs) is composed of receptors that bind peptides, such as secretin, glucagon, parathyroid hormone, and corticotropin releasing factor (CRF), which play critical physiological roles. These receptors, like all GPCRs, share a common structural motif
Eric Gutknecht et al.
Journal of neurochemistry, 104(4), 926-936 (2007-11-03)
Endogenous expression of the corticotropin-releasing factor type 2a receptor [CRF2(a)] but not CRF2(b) and CRF2(c) was observed in higher passage cultures of human Y79 retinoblastoma cells. Functional studies further demonstrated an increase in CRF2(a) mRNA and protein levels with higher
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S3884-250UG | 04061832677774 |
| S3884-.5MG | 04061832677750 |
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