S4026
甲基环己亚硝脲
别名:
N-（2-氯乙基）-N′-（4-甲基环己基）-N-亚硝基脲, 甲基-CCNU
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关于此项目
经验公式（希尔记法）:
C10H18ClN3O2
化学文摘社编号:
分子量:
247.72
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)
SMILES string
CC1CCC(CC1)NC(=O)N(CCCl)N=O
InChI key
FVLVBPDQNARYJU-UHFFFAOYSA-N
Application
常用于药理学研究，包括：
- 对营养敏感的筛选，用于将能量代谢从线粒体呼吸转变为糖酵解的药物
- CEOP方案结合司莫司汀，用于淋巴瘤患者的诱导化疗
- 应用于化疗的研究
signalword
Danger
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Roy E Smith et al.
Journal of the National Cancer Institute, 96(15), 1128-1132 (2004-08-05)
The National Surgical Adjuvant Breast and Bowel Project C-01 trial reported in 1988 that, for patients with adenocarcinoma of the colon, compared with surgery alone, 1) postoperative chemotherapy with 1-(2-chloroethyl)-3-(4-trans-methylcyclohexyl)-1-nitrosourea (i.e., MeCCNU or semustine), vincristine, and 5-fluorouracil was associated with
Nitrosourea chemotherapeutic agents: 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Report on carcinogens : carcinogen profiles, 12, 327-328 (2011-08-24)
Leonard C Hymes et al.
Pediatric transplantation, 11(5), 536-539 (2007-07-17)
Subclinical acute rejection (SCR) has been increasingly recognized in adult renal transplant recipients with the advent of surveillance biopsies. However, in children, surveillance biopsies are not routinely performed at most centers. Therefore, the incidence, predisposing factors, treatment, and clinical outcomes
Andreas Biffar et al.
European radiology, 20(11), 2679-2689 (2010-06-18)
To evaluate spin-lattice (T1) and spin-spin (T2) relaxation times as well as apparent diffusion coefficients (ADCs) of the fat and water components in the vertebral bone marrow (vBM) of patients with benign and malignant lesions. Forty-four patients were examined at
Ye Guo et al.
Oral oncology, 44(1), 23-30 (2007-02-20)
The objective of this analysis was to evaluate the efficacy and treatment outcome of CHOP and CHOP combined with nitrosourea chemotherapy in natural killer (NK)/T-cell lymphoma of the nasal cavity. Sixty-three patients with NK/T-cell lymphoma of the nasal cavity were
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