S4069
SL327
≥98% (HPLC), Mixture of E & Z isomers, solid
别名:
α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327
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选择规格
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关于此项目
经验公式（希尔记法）:
C16H12F3N3S
化学文摘社编号:
分子量:
335.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, protect from light
color
white to off-white
mp
127-128.2 °C
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
InChI
1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChI key
JLOXTZFYJNCPIS-FYWRMAATSA-N
Application
Biochem/physiol Actions
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro.
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)