S4197
Anti-Sirt6 (C-terminal) 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-NAD-dependent deacetylase sirtuin 6, Anti-SIR2-like protein 6, Anti-SIR2L6
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
14
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: suitable, western blot: 0.5-1 μg/mL using whole extracts of human U87 cells, western blot: 2.5-5 μg/mL using human HeLa cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SIRT6(51548)
General description
Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.
Immunogen
synthetic peptide corresponding to amino acids 330-348 of human Sirt6.
Application
Anti-Sirt6 (C-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
- immunohistochemistry
Biochem/physiol Actions
Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD+ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
常规特殊物品
此项目有
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
Mao Z, et al.
Proceedings of the National Academy of Sciences of the USA, 109(29), 11800-11805 (2012)
Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment
Balestrieri M L, et al.
Diabetes, 64(4), 1395-1406 (2015)
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses
Bauer I, et al.
The Journal of Biological Chemistry, 287(49), 40924-40937 (2012)
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells
Lappas, Martha
Mediators of Inflammation, 2012 (2012)
Longsen Han et al.
Scientific reports, 5, 15366-15366 (2015-10-21)
Sirt6, a member of the sirtuin family of NAD-dependent protein deacetylases, has been implicated in multiple biological processes. However, the roles of Sirt6 in meiosis have not been addressed. In the present study, by employing knockdown analysis in mouse oocytes
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