Merck
CN

S4250

Sigma-Aldrich

D -丝氨酸

≥98% (TLC)

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别名:
(R)-2-氨基-3-羟基丙酸, Ser, β-羟基丙氨酸
经验公式(希尔记法):
C3H7NO3
CAS号:
分子量:
105.09
Beilstein:
1721403
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.32

检测方案

≥98% (TLC)

形式

powder

technique(s)

ligand binding assay: suitable

颜色

white to off-white

application(s)

cell analysis

SMILES string

N[C@H](CO)C(O)=O

InChI

1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

InChI key

MTCFGRXMJLQNBG-UWTATZPHSA-N

Gene Information

human ... GRIN1(2902)

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相关类别

一般描述

D -丝氨酸是一种右旋氨基酸,存在于神经元、星形胶质细胞和小胶质细胞中。由丝氨酸消旋酶从 L -丝氨酸合成。消旋酶也可催化 D -丝氨酸分解成氨和丙酮酸。它可被 D -氨基酸氧化酶氧化为羟基丙酮酸。
D-丝氨酸是一种在哺乳动物大脑中表达的特殊氨基酸。

应用

D -丝氨酸已被用作人 1321N1 星形细胞瘤细胞中 D -氨基酸氧化酶 (DAO) 活性的底物。它还被用于大鼠脑室内给药以诱导抗伤害刺激效应。
D-丝氨酸已被用于防止 N-甲基 D-天冬氨酸受体 (NMDAR) 的甘氨酸依赖性脱敏,并研究了其对 NMDARs 的作用,以纠正部分坐骨神经结扎 (PSNL) 后大鼠的行为异常。

生化/生理作用

D -丝氨酸对于树突的正常发育、成神经细胞迁移是必需的,并且可能具有精神分裂症和抑郁症治疗潜力。在创伤性脑损伤 (TBI) 中 D -丝氨酸水平升高。
D-丝氨酸是激动剂和甘氨酸模拟物,在番木鳖不敏感的甘氨酸结合位点有活性,这类结合位点与 N-甲基-D-天门冬氨酸(NMDA)受体相关,也与抑制性突触后甘氨酸受体相关。它与谷氨酸一起,在各种生理过程中起作用,这些过程包括突触可塑性和受体传递。D-丝氨酸信号传导失调与神经退行性疾病和神经失调相关。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is the melting point for S4250, D-Serine?

    The melting point for this product is 228°C.

  7. What is the solubility of Product S4250, D-Serine?

    This product is soluble in water at a concentration of 50mg/mL. It is also soluble in 1M hydrochloric acid.  It is not soluble in ethanol or ether.

  8. Is Product S4250, D-Serine, suitable for human consumption?

    This product is not suitable for human consumption.  This product is intended primarily for laboratory research purposes and should not be used for any other purposes, including but not limited to, in vitro diagnostic purposes, in foods, drugs, medical devices, or cosmetics for humans or animals, or for other commercial purposes.

  9. Can D-Serine, Product No. S4250, be autoclaved?  

    Yes, solutions of this product can be autoclaved.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Imaging calcium concentration dynamics in small neuronal compartments.
Yasuda R
Science's STKE : Signal Transduction Knowledge Environment, 219, p15-p15 (2004)
D-serine as a gliotransmitter and its roles in brain development and disease
Van Horn MR, et al.
Frontiers in Cellular Neuroscience, 7, 39-39 (2013)
Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain
Ito M, et al.
Journal of Anesthesia, 28(2), 228-234 (2014)
High dose D-serine in the treatment of schizophrenia.
Kantrowitz JT
Schizophrenia Research, 121(1-3), 125-130 (2010)
Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury
Perez EJ, et al.
The Journal of Clinical Investigation, 127(8), 3114-3125 (2017)

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