S4441
D,L-Sulforaphane
≥90% (HPLC), liquid, phase II detoxification enzymes inducer
别名:
1-异硫氰酸基-4-（甲亚磺酰基）-丁烷
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关于此项目
经验公式（希尔记法）:
C6H11NOS2
化学文摘社编号:
分子量:
177.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
DL-萝卜硫素, ≥90% (HPLC), synthetic, liquid
SMILES string
CS(=O)CCCCN=C=S
InChI
1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
InChI key
SUVMJBTUFCVSAD-UHFFFAOYSA-N
biological source
synthetic
assay
≥90% (HPLC)
form
liquid
solubility
DMSO: soluble 40 mg/mL
H2O: insoluble
compatibility
for use with ABI 7500
shipped in
dry ice
storage temp.
−20°C
Quality Level
Application
用DL-萝卜硫素处理LNCaP前列腺癌细胞以研究其对雄激素受体的作用。用DL-萝卜硫素处理大鼠对研究其对马拉硫磷毒性的影响。
Biochem/physiol Actions
具有抗癌特性的II相解毒酶的选择性诱导物。在十字花科蔬菜（包括西兰花）中发现的有机硫化合物。
萝卜硫素是一种在十字花科蔬菜中发现的抗癌、抗微生物和抗糖尿病化合物。它可诱导产生解毒酶，例如可引起异生素转化的醌还原酶和谷胱甘肽S-转移酶。萝卜硫素还可增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性。它通过抑制LPS介导的iNOS、COX-2、IL-1β 和TNF-α的表达来调节炎症反应。
存储类别
10 - Combustible liquids
wgk
WGK 3
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Carmela Fimognari et al.
Mutation research, 635(2-3), 90-104 (2006-12-01)
A number of natural compounds with inhibitory effects on tumorigenesis have been identified from our diet. Several studies have documented the cancer-preventive activity of a significant number of isothiocyanates (ITCs), the majority of which occur in plants, especially in Cruciferous
A Kenneth MacLeod et al.
British journal of cancer, 115(12), 1530-1539 (2016-11-09)
Although the nuclear factor-erythroid 2-related factor 2 (NRF2) pathway is one of the most frequently dysregulated in cancer, it is not clear whether mutational status is a good predictor of NRF2 activity. Here we utilise four members of the aldo-keto
Verena Jeschke et al.
Frontiers in plant science, 8, 1995-1995 (2017-12-07)
Multiple lepidopteran larvae feed successfully on plants containing glucosinolates despite the diverse array of toxic and deterrent breakdown products, such as isothiocyanates (ITCs), formed upon plant damage. While much is known about how specialist lepidopterans metabolize and tolerate glucosinolates, there
Lars-Ove Brandenburg et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(6), 443-450 (2009-11-20)
The aim of this study was to investigate the signal transduction pathways involved in sulforaphane (SF) mediated inhibition of the inflammatory response to lipopolysaccharide (LPS). Additionally, we investigated the effects of SF and LPS on the activity of Nrf2. Primary
Y Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(6), 2399-2403 (1992-03-15)
Consumption of vegetables, especially crucifers, reduces the risk of developing cancer. Although the mechanisms of this protection are unclear, feeding of vegetables induces enzymes of xenobiotic metabolism and thereby accelerates the metabolic disposal of xenobiotics. Induction of phase II detoxication
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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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