S4451
Sal003
≥98% (HPLC)
别名:
(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
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关于此项目
经验公式（希尔记法）:
C18H15Cl4N3OS
化学文摘社编号:
分子量:
463.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Sal003, ≥98% (HPLC)
InChI key
TVNBASWNLOIQML-IZZDOVSWSA-N
SMILES string
Clc1ccc(NC(=S)NC(NC(=O)\C=C\c2ccccc2)C(Cl)(Cl)Cl)cc1
InChI
1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
protect from light
color
white to off-white
solubility
DMSO: ≥10 mg/mL
compatibility
for use with Bio-Rad CFX96
storage temp.
2-8°C
Quality Level
相关类别
Application
Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.
Biochem/physiol Actions
Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.
Sal003 is a potent and cell-permeable eIF-2a phosphatase inhibitor.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Mauro Costa-Mattioli et al.
Neuron, 61(1), 10-26 (2009-01-17)
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits
Charles A Hoeffer et al.
Neuron, 54(2), 186-189 (2007-04-20)
A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a
Cedric Darini et al.
Nature communications, 10(1), 2139-2139 (2019-05-16)
Trastuzumab is integral to HER2+ cancer treatment, but its therapeutic index is narrowed by the development of resistance. Phosphorylation of the translation initiation factor eIF2α (eIF2α-P) is the nodal point of the integrated stress response, which promotes survival or death
Raquel Amorim et al.
PLoS neglected tropical diseases, 11(7), e0005775-e0005775 (2017-07-18)
Zika virus (ZIKV), a member of the Flaviviridae family, is the most recent emerging arbovirus with pandemic potential. During infection, viruses trigger the host cell stress response, leading to changes in RNA translation and the assembly of large aggregates of
David Y A Dadey et al.
Molecular cancer research : MCR, 16(10), 1447-1453 (2018-07-12)
The aggressive nature and inherent therapeutic resistance of glioblastoma multiforme (GBM) has rendered the median survival of afflicted patients to 14 months. Therefore, it is imperative to understand the molecular biology of GBM to provide new treatment options to overcome
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