S4813
Anti-α1-Syntrophin (RA-16) antibody produced in rabbit
buffered aqueous solution, IgG fraction of antiserum
别名:
Anti-SNTA1
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (frozen sections)
microarray
western blot
microarray
western blot
Species reactivity:
rat
Citations:
8
Technique(s):
immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle
microarray: suitable
western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)
microarray: suitable
western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)
产品名称
Anti-α1-Syntrophin (RA-16) antibody produced in rabbit, buffered aqueous solution, IgG fraction of antiserum
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 60 kDa
species reactivity
rat
technique(s)
immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle
microarray: suitable
western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Snta1(20648)
rat ... Snta1(362242)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
α1-syntrophin (SNTA1) is a dystrophin-associated protein, that has four domains- a postsynaptic density protein-95/disc large/zona occludens-1 (PDZ) domain, two pleckstrin homology (PH1 and PH2) domains and a syntrophin unique (SU) domain. It is located on human chromosome 20q11.2. It is usually present in the peripheral cytoplasmic membrane.
Anti-α1-Syntrophin (RA-16) is developed in rabbit using a synthetic peptide corresponding to a sequence of mouse α1-syntrophin The syntrophins are a family of intracellular peripheral membrane proteins (58-60 kDa), comprising at least three isoforms α1, β1, and β2-syntrophins. Syntrophins in mammalian skeletal muscle have been shown to be part of a complex of proteins associated with dystrophin, the product of Duchenne/Becker muscular dystrophy gene. The C-terminal 57 amino acids region of syntrophins is highly conserved among the three isoforms, and may contain the binding site for dystrophin.
Application
Anti-α1-Syntrophin (RA-16) antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.
Biochem/physiol Actions
α1-Syntrophin recruit signaling proteins(2) to the membrane via association with the dystrophin complex.
α1-syntrophin (SNTA1) mutations results in LQTS (cardiac channelopathies like long QT syndrome). It modulates the development of adipocyte lipid droplet. It also participates in the survival signaling pathway in myoblasts. α1-syntrophin controls voltage-gated Na+ channels. It acts as a substrate for stress-activated protein kinase-3 (SAPK-3).
Immunogen
synthetic peptide corresponding to a sequence of mouse α1-syntrophin (amino acids 191-206 with N-terminally added lysine) conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
?-Syntrophin is involved in the survival signaling pathway in myoblasts under menadione-induced oxidative stress
Lim JA, et al.
Experimental Cell Research, 344(1), 1-10 (2016)
The adaptor protein alpha-syntrophin regulates adipocyte lipid droplet growth
Eisinger K, et al.
Experimental Cell Research, 345(1), 100-107 (2016)
gamma1-and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells
Piluso G, et al.
Test, 275(21), 15851-15860 (2000)
Dystrophin 71 and alpha1syntrophin in morpho-functional plasticity of rat supraoptic nuclei: Effect of saline surcharge and reversibly normal hydration
Sifi M, et al.
Acta Histochemica, 120(3), 187-195 (2018)
Clinical utility gene card for: long-QT syndrome (types 1-13)
Beckmann BM, et al.
European Journal of Human Genetics, 21(10) (2013)
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