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Merck
CN

S4881

葡萄球菌肠毒素B 来源于金黄色葡萄球菌

别名:

SEB, 肠毒素B,葡萄球菌

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352202
NACRES:
NA.25
MDL number:
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contains

sodium phosphate buffer as balance

Quality Segment

composition

Protein, ~25% Lowry

availability

not available in USA

impurities

Staphylococcal enterotoxin A (SEA), essentially free

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

General description

Staphylococcal Enterotoxin B (SEB) is a potent exotoxin produced by Staphylococcus aureus, classified as a superantigen due to its unique ability to activate T-cells non-specifically. This activation occurs through the cross-linking of T-cell receptors (TCRs) and major histocompatibility complex (MHC) class II molecules, leading to a massive release of cytokines and an exaggerated immune response. SEB is associated with food poisoning and toxic shock syndrome, making it a critical agent for studying the mechanisms of bacterial pathogenesis and immune dysregulation.
In addition to its role in infectious disease research, SEB serves as a valuable tool for investigating autoimmune conditions and the development of immunotherapies. Its ability to induce T-cell activation and proliferation makes it an important reagent for exploring T-cell biology, including differentiation, memory formation, and the effects of various immunomodulators.

Application

与 MHC II 类分子和 T 细胞受体(TCR)的特异性 Vβ 区结合的葡萄球菌肠毒素 B(SEB),可导致单核细胞/巨噬细胞和 T 淋巴细胞的激活,可用作超抗原和免疫系统激活剂。 SEB 可用作 SEB 检测系统开发中的参考材料。

Biochem/physiol Actions

T 淋巴细胞的超抗原。 与主要组织相容性复合体(MHC)抗原和 CD28 结合的免疫系统激活剂。

Packaging

包装尺寸基于蛋白质含量。


pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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