S5068
沙美特罗 羟萘甲酸盐
≥98% (HPLC), β2 adrenoceptor agonist, solid
别名:
(±) 4-羟基-a1-[[[6-(4-苯基丁氧基)己基]氨基]间-乙基]-1,3-苯二甲醇 羟萘甲酸盐, GR 33343X 羟萘甲酸盐
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关于此项目
经验公式（希尔记法）:
C25H37NO4 · C11H8O3
化学文摘社编号:
分子量:
603.75
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
沙美特罗 羟萘甲酸盐, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: slightly soluble, ethanol: slightly soluble, methanol: freely soluble
originator
GlaxoSmithKline
SMILES string
OC(=O)c1ccc2ccccc2c1O.OCc3cc(ccc3O)C(O)CNCCCCCCOCCCCc4ccccc4
InChI
1S/C25H37NO4.C11H8O3/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21;12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2;1-6,12H,(H,13,14)
InChI key
XTZNCVSCVHTPAI-UHFFFAOYSA-N
Gene Information
human ... ADRB2(154)
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Application
昔萘酸沙美特罗与人血清白蛋白结合用于研究兔的免疫反应。7
Biochem/physiol Actions
β2-肾上腺素能受体激动剂。
昔萘酸沙美特罗是一种 β2 型肾上腺素受体激动剂，具有更持久的支气管扩张作用和抗炎作用。它可以放松气道平滑肌、稳定肥大细胞并调节组胺的释放。昔萘酸沙美特罗对轻度哮喘、慢性阻塞性肺疾病特别有效。5,6
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Basak Isin et al.
PloS one, 7(12), e50186-e50186 (2013-01-10)
Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational ensembles of the proteins need to
Terence L Fodey et al.
Analytica chimica acta, 637(1-2), 328-332 (2009-03-17)
Haptens are low molecular weight compounds that are non-immunogenic and so must be conjugated to carrier molecules to elicit an immune response. Doses of 50-1000 microg protein conjugate have been suggested for immunisation of rabbits with hapten-protein immunogens. Although larger
Robert J Slack et al.
The Journal of pharmacology and experimental therapeutics, 344(1), 218-230 (2012-11-08)
Vilanterol trifenatate (vilanterol) is a novel, long-acting β(2)-adrenoceptor (β(2)-AR) agonist with 24 h activity. In this study, we describe the preclinical pharmacological profile of vilanterol using radioligand binding and cAMP studies in recombinant assays as well as human and guinea
Finney, P.A., et al.
British Journal of Pharmacology, 132, 1267-1270 (2001)
Claus Vogelmeier et al.
Respiratory medicine, 107(1), 75-83 (2012-10-30)
The objective of this study was to investigate the effect of tiotropium compared with salmeterol on exacerbations in patients with moderate (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage II) chronic obstructive pulmonary disease (COPD) and those naïve to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S5068-10MG | 04061836937126 |
| S5068-50MG | 04061832093581 |
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