产品名称
抗 α-突触核蛋白抗体，小鼠单克隆, clone Syn211, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
Syn211, monoclonal
form
buffered aqueous solution
mol wt
antigen 19 kDa
species reactivity
zebra finch, human
should not react with
rat, mouse
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.25 μg/mL using recombinant human α·-synuclein.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SNCA(6622)
Biochem/physiol Actions
少突胶质细胞中α-突触核蛋白累积会导致髓鞘质损失并引起神经变性，从而导致多系统萎缩。目前确知，α-突触核蛋白可诱导少突胶质细胞成熟。其编码的蛋白质是公认的重要路易体聚集体，参与帕金森病的发病机制。
目前确知，α-突触核蛋白可诱导少突胶质细胞成熟。少突胶质细胞中α-突触核蛋白累积会导致髓鞘质损失并引起神经变性，从而导致多系统萎缩。SNCA 基因突变会导致帕金森病。
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除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
SNCA（突触核蛋白α）基因定位于人类染色体 4q22.1上。该基因编码一种名为α-突触核蛋白的小突触蛋白。
SNCA（突触核蛋白α）基因编码一个 140 个氨基酸的蛋白α-突触核蛋白，位于人类染色体4q21-23上。
Immunogen
重组人 α-突触核蛋白。
Other Notes
Physical form
溶于0.01M磷酸盐缓冲盐水，pH 7.4，含有1%牛血清白蛋白以及15 mM叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
Kavita Prasad et al.
Brain pathology (Zurich, Switzerland), 22(6), 811-825 (2012-03-29)
The role of Lewy bodies, Lewy neurites and α-synuclein (αSYN) in the pathophysiology and diagnosis of Parkinson's disease (PD) is unclear. We used postmortem human tissue, a panel of antibodies (Abs) and confocal microscopy to examine the three-dimensional neurochemical anatomy
Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration
Malkus KA, et al.
Neurobiology of Disease, 46(3), 732-744 (2012)
Anna E Cartier et al.
PloS one, 7(4), e34713-e34713 (2012-04-20)
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by genetic and environmental factors. Abnormal accumulation and aggregation of alpha-synuclein (a-syn) within neurons, and mutations in the a-syn and UCH-L1 genes have been shown to play a role in the
Interactions of Pathological Hallmark Proteins
Olah J, et al.
The Journal of Biological Chemistry, 286(39), 34088-34100 (2011)
α-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.
Miller DW, et al.
Neurology, 62(10), 1835-1838 (2004)
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