Sanguinarine chloride hydrate

Name: Sanguinarine chloride hydrate
Brand: SIGMA

≥98% (HPLC)

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₄ClNO₄ · xH₂O

化学文摘社编号:

5578-73-4

分子量:

367.78 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24278199

UNSPSC Code:

12352200

MDL number:

MFCD00012126

Assay:

≥98% (HPLC)

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属性

Quality Segment

100

assay

≥98% (HPLC)

solubility

H₂O: slightly soluble <0.3 mg/mL, methanol: 3.8 mg/mL

SMILES string

[Cl-].C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14

InChI

1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;/h2-8H,9-10H2,1H3;1H/q+1;/p-1

InChI key

GIZKAXHWLRYMLE-UHFFFAOYSA-M

说明

Application

Sanguinarine chloride hydrate was tested for anti-schistosomal activities against Schistosoma mansoni.⁹ It was tested for anti-lipase activity against Candida rugosa lipase.¹⁰

Sanguinarine chloride hydrate yields clear, orange solution in methanol at 20 mg/ml.

Biochem/physiol Actions

A natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Has antiproliferative, pro-apoptosis effects in some cancer cell lines.

A natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties.

Sanguinarine is a benzophenanthridine alkaloid isolated from plants belonging to the family Papaveracea. It exhibits anti-bacterial, anti-fungal, anti-inflammatory and anti-cancer properties. It induces cell cycle arrest and sensitizes cancer cells to apoptosis by activating TNF-related apoptosis inducing ligand.^6,7 It inhibits STAT3, MMP-2, MMP-9, interacts with glutathione, induces generation of ROS, disrupts the microtubule assembly and causes DNA damage resulting the death of the cancer cells.^6,7,8