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Merck
CN

S6135

Somatostatin 28

≥97% (HPLC)

别名:

Prosomatostatin

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关于此项目

经验公式（希尔记法）:
C137H207N41O39S3
化学文摘社编号:
73032-94-7
分子量:
3148.56
NACRES:
NA.32
PubChem Substance ID:
24899687
UNSPSC Code:
51111800
MDL number:
MFCD00076772

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产品名称

Somatostatin 28, ≥97% (HPLC)

InChI key

GGYTXJNZMFRSLX-UHFFFAOYSA-N

SMILES string

CSCCC(NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(N)CO)C(=O)NC(C)C(=O)N2CCCC2C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NCC(=O)NC3CSSCC(NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc4ccccc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(Cc5c[nH]c6ccccc56)NC(=O)C(Cc7ccccc7)NC(=O)C(Cc8ccccc8)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC3=O)C(C)O)C(C)O)C(O)=O

InChI

1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)

assay

≥97% (HPLC)

form

powder

mol wt

3148.56

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

>70% (peptide content)

technique(s)

activity assay: suitable

solubility

water: 1 mg/mL, clear, colorless

UniProt accession no.

P61278

storage temp.

−20°C

Quality Level

200

Gene Information

human ... SST(6750)

Application

Somatostatin 28 has been used:

  • to study the effects of somatostatin in regulating hepatic growth hormone sensitivity
  • to study its effects on insulin-like growth factor-I receptor expression in the gills of Oncorhynchus mykiss (a teleost fish)
  • to assess the effects of somatostatinon GH (growth hormone)-stimulated IGF-I (insulin-like growth factor-I) expression

Biochem/physiol Actions

Somatostatin action is delivered with help of five different receptor subtypes (sst1 to sst5).
Somatostatin plays an important role in regulating the metabolism of other hormones such as growth hormone, insulin, IGF-1 (insulin-like growth factor 1), glucagon, glucagon-like peptide and gastrin. Somatostatin has both regulatory and inhibitory functions. It retards gastrointestinal motility and gallbladder contraction, suppresses gut exocrine secretion and reduces epithelial proliferation. Somatostatin is associated with intestinal nutrient absorption and blood flow regulation. This peptide hormone is believed to inhibit cell proliferation and promote apoptosis. Somatostatin acts as a neurotransmitter and neuromodulator, and is also associated in maintaining water balance.Pituitary somatostatin receptor signaling is implicated in the inhibition of adenylyl cyclase- cyclic adenosine 3′,5′-monophosphate (cAMP)- protein kinase A (PKA) pathway. Pituitary somatostatin activity is also involved in regulation of various pathways including guanylyl cyclase and nitric oxide (NO), mitogen-activated protein kinase (MAPK) and protein kinase B (PI3K/Akt).

General description

Research area: Neuroscience

The SST gene is mapped to human chromosome 3q27.3. Both SST-14 and SST-28 are cyclic peptide.
The somatostatin gene codes for a peptide hormone containing 14 and 28 amino acid moieties. SST-14 is highly expressed in the central nervous system and peripheral organs. SST-28 is mainly expressed in enteroendocrine cells of the intestine.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000503199
0000503199
0000401925
0000401923
0000401923

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Anat Ben-Shlomo et al.
Trends in endocrinology and metabolism: TEM, 21(3), 123-133 (2010-02-13)
Somatotropin-release inhibitory factor (SRIF) is a major regulator of pituitary function, mostly inhibiting hormone secretion and to a lesser extent pituitary cell growth. Five SRIF receptor subtypes (SSTR1-5) are ubiquitously expressed G-protein coupled receptors. In the pituitary, SSTR1, 2, 3
Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26. 2--q29 in squamous cell carcinoma of the lung
Kang JU, et al.
BMC Cancer, 9(1), 237-237 (2009)
Somatostatin regulates hepatic growth hormone sensitivity by internalizing growth hormone receptors (GHR) and by decreasing transcription of GHR mRNAs
Very NM and Sheridan MA
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology (2007)
Daniela Modena et al.
Cancers, 15(13) (2023-07-14)
Somatostatin receptor (SSTR) agonists have been extensively used for treating neuroendocrine tumors. Synthetic therapeutic agonists showing selectivity for SSTR2 (Octreotide) or for SSTR2 and SSTR5 (Pasireotide) have been approved for the treatment of patients with acromegaly and Cushing's syndrome, as
Somatostatin regulates hepatic growth hormone sensitivity by internalizing growth hormone receptors and by decreasing transcription of growth hormone receptor mRNAs
Nicole M
Physiology (Bethesda, MD) (2007)
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