Anti-phospho-S6-Kinase (pThr³⁸⁹) antibody produced in rabbit

p70 S6 kinase or p70S6K is a protein that belongs to Ser/Thr protein kinase family. It has a crucial role in cell growth and G1 cell cycle progression. It also has a pivotal role in phosphorylating eEF2k at a conserved serine residue and hence regulating the protein synthesis. Rabbit anti-phospho-(p70S6K) antibody can identify p70 S6 kinase and p85 S6 kinase when phosphorylated at (Thr³⁸⁹). Anti-phospho-S6-kinase (pThr³⁸⁹) antibody reacts specifically with p70 S6 kinase of rat, mouse and human. This product can also detect few phosphorylated isoforms of Protein Kinase C when present at high level in cells.

A synthetic phospho-(Thr³⁸⁹) peptide corresponding to residues around (Thr³⁸⁹) of human p70 S6 kinase, coupled to KLH.

Anti-phospho-S6-kinase (pThr³⁸⁹) antibody can be used in western blotting (chemiluminescent) (diluted 1:1000) using serum-treated NIH3T3 cell extract or insulin-treated HeLa, COS, and C6 cell extracts.

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

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