S6324
Monoclonal Anti-SNX6 antibody produced in mouse
clone SNX6-76, ascites fluid, buffered aqueous solution
别名:
Anti-MSTP010, Anti-Sorting Nexin 6, Anti-TFAF2, Anti-Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SNX6-76, monoclonal
Application:
ELISA (i), WB
Citations:
11
isotype
IgA
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
SNX6-76, monoclonal
form
buffered aqueous solution
mol wt
antigen ~47 kDa
species reactivity
mouse, human, bovine, rat
packaging
antibody small pack of 25 μL
technique(s)
indirect ELISA: suitable, western blot: 1:2,500-1:5,000 using total extracts of A549 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SNX6(58533)
mouse ... Snx6(72183)
rat ... Snx6(362738)
General description
Monoclonal Anti-SNX6 (mouse IgA isotype) is derived from the hybridoma SNX6-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SNX6 (sorting nexin 6) is a BACE1 (Β-site APP cleaving enzyme-1)-associated protein and a constituent of retromer. It belongs to the sorting nexin (SNX) family that has a PX (Phox homology) domain at its amino terminus and a BAR (Bin/amphiphysin/Rvc) domain at its carboxyl region. It is located on chromosome 14q13.
Application
Monoclonal Anti-SNX6 antibody produced in mouse has been used in immunoblotting and ELISA.
Biochem/physiol Actions
SNX6 (sorting nexin 6) helps in retrograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin. Interaction of SNX6 with breast cancer metastasis suppressor-1 induces transcriptional repression. It helps in the synthesis of lamin A and its transportation to the nuclear envelope .
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope
Gonzalez-Granado JM, et al.
PLoS ONE, 9(12) (2014)
Akshay Bareja et al.
The Journal of biological chemistry, 293(17), 6449-6459 (2018-03-14)
The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously thought. Moreover, it has
Ana Jimenez-Orgaz et al.
The EMBO journal, 37(2), 235-254 (2017-11-22)
Retromer is an endosomal multi-protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional retromer function in controlling the activity and localization of the late endosomal small GTPase RAB7. Surprisingly
Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes
Kamnasaran D, et al.
Genomics, 85(5), 608-621 (2005)
Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression
Rivera J, et al.
Journal of Cellular Biochemistry, 111(6), 1464-1472 (2010)
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