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S6324

Sigma-Aldrich

Monoclonal Anti-SNX6 antibody produced in mouse

clone SNX6-76, ascites fluid, buffered aqueous solution

别名:
Anti-Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2, Anti-Sorting Nexin 6, Anti-TFAF2, Anti-MSTP010
NACRES:
NA.41

质量水平

200

生物来源

mouse

偶联物

unconjugated

抗体形式

ascites fluid

antibody product type

primary antibodies

克隆

SNX6-76, monoclonal

形式

buffered aqueous solution

分子量

antigen ~47 kDa

species reactivity

rat, human, bovine, mouse

包装

antibody small pack of 25 μL

technique(s)

indirect ELISA: suitable
western blot: 1:2,500-1:5,000 using total extracts of A549 cells

同位素/亚型

IgA

UniProt登记号

运输

dry ice

储存温度

−20°C

Gene Information

human ... SNX6(58533)
mouse ... Snx6(72183)
rat ... Snx6(362738)

一般描述

Monoclonal Anti-SNX6 (mouse IgA isotype) is derived from the hybridoma SNX6-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SNX6 (sorting nexin 6) is a BACE1 (Β-site APP cleaving enzyme-1)-associated protein and a constituent of retromer. It belongs to the sorting nexin (SNX) family that has a PX (Phox homology) domain at its amino terminus and a BAR (Bin/amphiphysin/Rvc) domain at its carboxyl region. It is located on chromosome 14q13.

应用

Monoclonal Anti-SNX6 antibody produced in mouse has been used in immunoblotting and ELISA.

生化/生理作用

SNX6 (sorting nexin 6) helps in retrograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin. Interaction of SNX6 with breast cancer metastasis suppressor-1 induces transcriptional repression. It helps in the synthesis of lamin A and its transportation to the nuclear envelope .

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

分析证书

原产地证书 (CofO)

Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes
Kamnasaran D, et al.
Genomics, 85(5), 608-621 (2005)
Akshay Bareja et al.
The Journal of biological chemistry, 293(17), 6449-6459 (2018-03-14)
The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously thought. Moreover, it has
Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope
Gonzalez-Granado JM, et al.
PLoS ONE, 9(12) (2014)
Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression
Rivera J, et al.
Journal of Cellular Biochemistry, 111(6), 1464-1472 (2010)
Ana Jimenez-Orgaz et al.
The EMBO journal, 37(2), 235-254 (2017-11-22)
Retromer is an endosomal multi-protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional retromer function in controlling the activity and localization of the late endosomal small GTPase RAB7. Surprisingly

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