S6508
正钒酸钠
synthetic (organic), ≥90% (titration), protein tyrosine phosphatase inhibitor, crystalline powder
别名:
Trisodium vanadate
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关于此项目
线性分子式:
Na3VO4
化学文摘社编号:
分子量:
183.91
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
237-287-9
MDL number:
产品名称
正钒酸钠, ≥90% (titration)
biological source
synthetic (organic)
Quality Level
assay
≥90% (titration)
form
crystalline powder
reaction suitability
reagent type: catalyst
core: vanadium
color
white to off-white
mp
850-866 °C (lit.)
solubility
H2O: soluble
SMILES string
[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
InChI
1S/3Na.4O.V/q3*+1;;3*-1;
InChI key
IHIXIJGXTJIKRB-UHFFFAOYSA-N
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Application
正钒酸钠被用于制备胰岛素受体激酶脱磷酸化检测的终止液。26 它是用于开发利用表面固定抗体的Matrix ChIP的试剂之一。27
Biochem/physiol Actions
抑制 ATP 酶、碱性磷酸酶和酪氨酸磷酸酶。在酸性 PH 值下形成的十钒酸盐可抑制肌醇基 1,4,5-三磷酸 (IP3)-诱导 Ca2+ 从内分泌细胞中的释放以及阻止 IP3 与其受体在脑组织中的结合。
正钒酸钠可抑制辐射触发的p53介导的细胞凋亡激活。它减少了小鼠全身辐照引起的造血综合征、造血功能和延迟遗传毒性效应的不利影响。24 正钒酸盐与甲萘醌联合使用，可以防止脱落人胶质瘤细胞在抗癌药作用下发生迁移。25
Features and Benefits
《受体分类和信号转导》手册的 磷蛋白磷酸酶（酪氨酸） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是激酶磷酸酶生物学研究的特色产品。点击此处 ，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
C Cerella et al.
Cell death & disease, 6, e1782-e1782 (2015-06-13)
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis procera, which is
Christopher N J Young et al.
Autophagy, 11(1), 113-130 (2015-02-24)
P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a considerably wider permeation. However, the functional significance of the movement of molecules through the large pore (LP) and the intracellular signaling events involved are not
Serena Orlando et al.
Nucleic acids research, 43(14), 6860-6873 (2015-06-15)
Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G1 phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk
Roser Buscà et al.
BMC evolutionary biology, 15, 179-179 (2015-09-04)
The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due
Erika López-Arribillaga et al.
Development (Cambridge, England), 142(1), 41-50 (2014-12-07)
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S6508-250G | 04061836959432 |
| S6508-10G | 04061835513222 |
| S6508-50G | 04061835559077 |
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