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Merck
CN

S6626

Sigma-Aldrich

毒毛旋花子苷元

cardiotonic steroid

别名:

3β,5,14-三羟基-19-氧-5β,20(22)-强心苷, ;毒毛旋花苷配基, K-毒毛旋花子甙元, 毒毛旋花子甙元, 毒毛旋花子苷K, 毒毛旋花子苷元, 毒毛旋花甙元, 羊角拗定, 羊角拗甾醇

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关于此项目

经验公式(希尔记法):
C23H32O6
化学文摘社编号:
分子量:
404.50
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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产品名称

毒毛旋花子苷元,

储存温度

−20°C

SMILES字符串

C[C@@]12[C@@](CC[C@@H]2C(CO3)=CC3=O)(O)[C@]4([H])CC[C@]5(O)C[C@@H](O)CC[C@]5(C([H])=O)[C@@]4([H])CC1

InChI

1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3

InChI key

ODJLBQGVINUMMR-UHFFFAOYSA-N

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应用

毒毛旋花子甙元可用于合成乙酰毒毛旋花子甙元,已研究其对狗隐静脉神经递质释放的影响。3

生化/生理作用

毒毛旋花子甙元(Strophanthidin)是一种强心苷,可提高心肌细胞中的Na+/K+-ATP酶活性。1在兔肾皮质切片中,它可降低钾含量,提高钠含量。2

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Beni Shpak et al.
European journal of pharmacology, 553(1-3), 196-204 (2006-11-03)
Previous studies demonstrated that the purified endogenous inhibitor (NCX(IF)) of the cardiac Na(+)/Ca(2+) exchanger (NCX1) has the capacity to modulate cardiac muscle contractility. Here, we tested the effects of purified NCX(IF) on arrhythmias induced by ouabain in the atria and
Mark R Fowler et al.
Cardiovascular research, 62(3), 529-537 (2004-05-26)
Recent work has suggested that Na(+)/Ca(2+) exchange (NCX) and L-type Ca(2+) current (I(Ca)) are located predominantly in the t-tubules of cardiac ventricular myocytes, which therefore represent a microdomain for the regulation of intracellular Na(+) (Na(i)) and Ca(2+) (Ca(i)). The aim
Sara Arganda et al.
Nature neuroscience, 10(11), 1467-1473 (2007-10-02)
Pump activity is a homeostatic mechanism that maintains ionic gradients. Here we examined whether the slow reduction in excitability induced by sodium-pump activity that has been seen in many neuronal types is also involved in neuronal coding. We took intracellular
L W Woods et al.
Veterinary pathology, 41(3), 215-220 (2004-05-11)
Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding
Niaz Ahmad et al.
Kidney international, 66(1), 77-90 (2004-06-18)
Tissue damage at the time of organ transplantation has a negative impact on the subsequent success of the procedure, both in the immediate and longer term. Hypothermia is the principal element used to prolong organ viability ex vivo, but paradoxically

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