Merck
CN
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文件

安全信息

S6883

Sigma-Aldrich

P 物质 乙酸盐 水合物

≥95% (HPLC), powder

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经验公式（希尔记法）:
C63H98N18O13S · xC2H4O2 · yH2O
CAS号:
137348-11-9
分子量:
1347.63 (anhydrous free base basis)
Beilstein:
5153552
PubChem化学物质编号:
24899725
NACRES:
NA.32

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

分子量

1348 Da by calculation (Average Mass)

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white

溶解性

0.1 M acetic acid: 1 mg/mL

UniProt登记号

P20366

储存温度

−20°C

SMILES字符串

[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

InChI

1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1

InChI key

VHKFRLDSEZYWAC-CIYRQLMPSA-N

基因信息

human ... TAC1(6863)

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相关类别

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

一般描述

Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

应用

Substance P acetate salt hydrate has been:

  • used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
  • administered in central nucleus (ACE) in rat to study its positive reinforcing effects
  • used in competition binding assays
  • used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

生化/生理作用

NK-1 激动剂；强效血管扩张剂和抗高血压剂；诱导唾液分泌；增加毛细血管通透性；诱导肥大细胞脱颗粒；感觉（疼痛）传入中的假定神经递质。
Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

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The role of substance P in inflammatory disease.
O'Connor TM
Journal of Cellular Physiology, 201(2), 167-180 (2004)
Wei Wang et al.
American journal of physiology. Heart and circulatory physiology, 297(2), H726-H734 (2009-06-16)
Muscular lymphatics use both phasic and tonic contractions to transport lymph for conducting their vital functions. The molecular mechanisms regulating lymphatic muscle contractions are not well understood. Based on the well-established finding that the phosphorylation of myosin light chain 20
Erika Kertes et al.
Behavioural brain research, 205(1), 307-310 (2009-06-27)
Substance P (SP) can have positive reinforcing or aversive properties, depending on the dose used and the site of action in the brain. Experimental findings suggest that the amygdala is involved in reward-related processes. The presence of SP-immunoreactive fibers and
Eliska Mistrova et al.
Neuropeptides, 58, 41-51 (2015-12-27)
This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions
Neurobiology of substance P and the NK1 receptor.
Mantyh PW
The Journal of Clinical Psychiatry, 63, 6-10 (2002)
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