S6951
Surfen水合物
≥98% (HPLC), Heparan sulfate antagonist, powder
别名:
1,3-二（4-氨基-2-甲基-6-喹啉）脲水合物, NSC 12155, N，N′-双（4-氨基-2-甲基-6-喹啉）脲, 二-2-甲基-4-氨基喹啉-6-脲水合物, 双氨甲喹脲, 氨喹脲, 氨基尿苷
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关于此项目
经验公式（希尔记法）:
C21H20N6O · xH2O
化学文摘社编号:
分子量:
372.42 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Surfen水合物, ≥98% (HPLC)
SMILES string
O.Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1
InChI
1S/C21H20N6O.H2O/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20;/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28);1H2
InChI key
UXYZYUHSZVKWTR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Application
Surfen水合物可用作肝素的拮抗剂。
Surfen水合物已用于抑制人类胚胎肾细胞中的多个电压门控钙通道。
Surfen水合物已用于抑制人类胚胎肾细胞中的多个电压门控钙通道。
Biochem/physiol Actions
Surfen是一种硫酸乙酰肝素拮抗剂，最初于三十年代后期开发，作为生产长效胰岛素的赋形剂。 硫酸乙酰肝素（HS）在结构上与肝素相关，但每个二糖含有较少的硫酸根基团，并且几乎仅存在于蛋白聚糖的蛋白核心上，蛋白聚糖在质膜上显示或分泌到细胞外基质中。Surfen与糖胺聚糖（GAG）/HS的链结合并阻止酶和蛋白质的结合，从而充当HS拮抗剂。 Surfen比鱼精蛋白（一种临床使用的肝素拮抗剂）更有效。
Surfen是硫酸乙酰肝素拮抗剂。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Elodie Monsellier et al.
PloS one, 15(8), e0237328-e0237328 (2020-08-14)
α-Synuclein (αSyn) fibrils spread from one neuronal cell to another. This prion-like phenomenon is believed to contribute to the progression of the pathology in Parkinson's disease and other synucleinopathies. The binding of αSyn fibrils originating from affected cells to the
urfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain
Rivas-Ramirez P, et al.
Pflugers Archiv : European Journal of Physiology, 469, 1325-1334 (2017)
Carl W White et al.
iScience, 24(1), 102011-102011 (2021-01-26)
Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quantify secretion and receptor binding of native chemokines in live cells
Sapthaswaran Veerapathiran et al.
eLife, 9 (2020-11-26)
Wnt3 proteins are lipidated and glycosylated signaling molecules that play an important role in zebrafish neural patterning and brain development. However, the transport mechanism of lipid-modified Wnts through the hydrophilic extracellular environment for long-range action remains unresolved. Here we determine
Anne Marie W Bartosch et al.
Scientific reports, 11(1), 11386-11386 (2021-06-02)
This study aimed to clarify the role of glypican-1 and PECAM-1 in shear-induced nitric oxide production in endothelial cells. Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein endothelial
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