S7067
SB 202190
≥98% (HPLC), powder, p38 MAP kinase inhibitor
别名:
4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑
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关于此项目
经验公式（希尔记法）:
C20H14FN3O
化学文摘社编号:
分子量:
331.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SB 202190, ≥98% (HPLC)
SMILES string
Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI key
QHKYPYXTTXKZST-UHFFFAOYSA-N
InChI
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
assay
≥98% (HPLC)
form
powder
color
faintly yellow, to beige
solubility
DMSO: 10 mg/mL, clear
originator
GlaxoSmithKline
storage temp.
2-8°C
Quality Level
Gene Information
human ... MAPK14(1432)
Application
SB 202190用于：
- 研究p38丝裂原活化蛋白激酶(MAPK)信号传导对于实现呼肠孤病毒感染的作用
- 作为p38α抑制剂，体内研究其对APC Min/+ 小鼠结肠粘膜组织中腺癌发生发展或进展的作用。
- 作为基底细胞基础培养基组分，培养基底祖细胞。
- 作为正常内膜和内膜肿瘤培养基用于类器官培养。
SB 202190被用于抑制MCF7细胞5、小鼠巨噬细胞6和HepG2细胞的p38活化。7
Biochem/physiol Actions
SB 202190是p38 MAP激酶的高选择性、有效的和细胞渗透性抑制剂。SB 202190在活性激酶的ATP口袋内结合（Kd = 38nM，在重组人p38中测量得到），并选择性抑制p38α和β亚型。
Features and Benefits
该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。
General description
SB202190可增强NPC1缺陷小鼠神经干细胞的自我更新能力。
Legal Information
根据GlaxoSmithKline协议出售，用于研究目的
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling
Yang SR, et al.
Journal of Separation Science, 24(2), 292-298 (2006)
Uncoupling p38? nuclear and cytoplasmic functions and identification of two p38? phosphorylation sites on ?-catenin: implications for the Wnt signaling pathway in CRC models
Lepore Signorile M, et al.
Journal of Separation Science, 13(1), 223-223 (2023)
Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay
Rodenburg LW, et al.
STAR protocols, 4(3), 102337-102337 (2023)
p38 Mitogen-Activated Protein Kinase Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Capsid Uncoating, and Postuncoating Steps
Mohamed A, et al.
American journal of virology, 97(2), e0000923-e0000923 (2023)
Edward Thorp et al.
The Journal of biological chemistry, 286(38), 33335-33344 (2011-08-11)
Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory signaling. Proteolytic cleavage of MerTK at an unidentified site leads to shedding of its soluble ectodomain (soluble
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