S7198
西维来司 钠盐 水合物
≥98% (HPLC), HNE inhibitor, solid
别名:
EI 546 钠盐 水合物, Elaspol 钠盐 水合物, LY 544349 钠盐 水合物, 奥诺-5046 钠盐 水合物, 新戊酸 o-（对羟基苯磺酰胺）马尿酸 钠盐 水合物
Product Name
西维来司 钠盐 水合物, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
DMSO: 10 mg/mL, clear
储存温度
room temp
SMILES字符串
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
InChI
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key
BTGNGJJLZOIYID-UHFFFAOYSA-N
相关类别
应用
西维来司钠水合物可用于抑制人中性粒细胞弹性蛋白酶介导的细胞信号传导。
生化/生理作用
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂 (IC50 = 44 nM，Ki = 0.2 μM)。它也抑制从兔、大鼠、仓鼠和小鼠中获得的白细胞弹性蛋白酶（IC50 = 19 至 49 nM）。但即使在 100 μM 时，它也不抑制胰蛋白酶、凝血酶、纤溶酶、血浆激肽释放酶、胰激肽释放酶、糜蛋白酶和组织蛋白酶 G。在体内研究中，它抑制仓鼠肺出血（ID50=82 μMg/kg）气管内给药和静脉给药增加豚鼠皮肤毛细血管通透性 (ID50 = 9.6 mg/kg)，均由人中性粒细胞弹性蛋白酶诱导。
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂。
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yufeng Wang et al.
Frontiers in immunology, 13, 841445-841445 (2022-04-29)
The rate of complete remission of acute promyelocytic leukemia (APL) is currently over 90% because of the use of all-trans retinoic acid (ATRA) with arsenic trioxide (ATO). However, hemorrhagic mortality has emerged as the most significant barrier to APL-induced remission.
Kasturi Ganguly et al.
Frontiers in immunology, 13, 930449-930449 (2022-07-26)
Surfactant protein D (SP-D), a pattern recognition molecule, is emerging as a potent anti-tumoural innate immune defense molecule in a range of cancers. Previously, SP-D expression was found to be significantly downregulated at the malignant sites of human prostate adenocarcinoma
Eliana Pivetta et al.
Clinical science (London, England : 1979), 130(14), 1221-1236 (2016-02-28)
Lymphatic vasculature critically depends on the connections of lymphatic endothelial cells with the extracellular matrix (ECM), which are mediated by anchoring filaments (AFs). The ECM protein EMILIN1 is a component of AFs and is involved in the regulation of lymphatic
Daniel Appelgren et al.
Cells, 9(1) (2019-12-28)
Neutrophils operate as part of the innate defence in the skin and may eliminate the Borrelia spirochaete via phagocytosis, oxidative bursts, and hydrolytic enzymes. However, their importance in Lyme neuroborreliosis (LNB) is unclear. Neutrophil extracellular trap (NET) formation, which is
Seigo Miyoshi et al.
Drug design, development and therapy, 7, 305-316 (2013-04-19)
Neutrophil elastase plays a crucial role in the development of acute lung injury (ALI) in patients with systemic inflammatory response syndrome (SIRS). The clinical efficacy of the neutrophil elastase inhibitor, sivelestat, for patients with ALI associated with SIRS has not
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