S7198
西维来司 钠盐 水合物
≥98% (HPLC), HNE inhibitor, solid
别名:
EI 546 钠盐 水合物, Elaspol 钠盐 水合物, LY 544349 钠盐 水合物, 奥诺-5046 钠盐 水合物, 新戊酸 o-（对羟基苯磺酰胺）马尿酸 钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C20H22N2O7S · xNa+ · yH2O
化学文摘社编号:
分子量:
434.46 (anhydrous free acid basis)
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
西维来司 钠盐 水合物, ≥98% (HPLC), solid
SMILES string
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
InChI
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key
BTGNGJJLZOIYID-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
Quality Level
Application
西维来司钠水合物可用于抑制人中性粒细胞弹性蛋白酶介导的细胞信号传导。
Biochem/physiol Actions
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂 (IC50 = 44 nM，Ki = 0.2 μM)。它也抑制从兔、大鼠、仓鼠和小鼠中获得的白细胞弹性蛋白酶（IC50 = 19 至 49 nM）。但即使在 100 μM 时，它也不抑制胰蛋白酶、凝血酶、纤溶酶、血浆激肽释放酶、胰激肽释放酶、糜蛋白酶和组织蛋白酶 G。在体内研究中，它抑制仓鼠肺出血（ID50=82 μMg/kg）气管内给药和静脉给药增加豚鼠皮肤毛细血管通透性 (ID50 = 9.6 mg/kg)，均由人中性粒细胞弹性蛋白酶诱导。
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂。
存储类别
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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