S7198
西维来司 钠盐 水合物
≥98% (HPLC), HNE inhibitor, solid
别名:
EI 546 钠盐 水合物, Elaspol 钠盐 水合物, LY 544349 钠盐 水合物, 奥诺-5046 钠盐 水合物, 新戊酸 o-（对羟基苯磺酰胺）马尿酸 钠盐 水合物
产品名称
西维来司 钠盐 水合物, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
DMSO: 10 mg/mL, clear
储存温度
room temp
SMILES字符串
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
InChI
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key
BTGNGJJLZOIYID-UHFFFAOYSA-N
应用
西维来司钠水合物可用于抑制人中性粒细胞弹性蛋白酶介导的细胞信号传导。
生化/生理作用
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂 (IC50 = 44 nM，Ki = 0.2 μM)。它也抑制从兔、大鼠、仓鼠和小鼠中获得的白细胞弹性蛋白酶（IC50 = 19 至 49 nM）。但即使在 100 μM 时，它也不抑制胰蛋白酶、凝血酶、纤溶酶、血浆激肽释放酶、胰激肽释放酶、糜蛋白酶和组织蛋白酶 G。在体内研究中，它抑制仓鼠肺出血（ID50=82 μMg/kg）气管内给药和静脉给药增加豚鼠皮肤毛细血管通透性 (ID50 = 9.6 mg/kg)，均由人中性粒细胞弹性蛋白酶诱导。
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂。
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jessica Fox et al.
International journal of radiation oncology, biology, physics, 85(1), 215-222 (2012-08-30)
We previously reported increased numbers of neutrophils to be associated with the development of the radiation-induced lung responses of alveolitis (pneumonitis) and fibrosis in mice. In the present study we investigated whether CXC receptor 1 and 2 antagonism with DF2156A
Naoya Fujino et al.
Experimental lung research, 38(1), 28-36 (2011-12-14)
Excess production of neutrophil elastase contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the role of neutrophil elastase in the repair process following ALI/ARDS is not well understood. The objective of this
Shuoqi Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(9), e21835-e21835 (2021-08-28)
Circulating neutrophil extracellular traps (NETs) resistant to t-PA have not been studied completely although NETs in thrombi may contribute to tissue plasminogen activator (t-PA) resistance. This research intended to elucidate whether circulating NETs are associated with t-PA resistance and the
Katja Herges et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 18(4), 398-408 (2012-02-22)
The pathology of neuromyelitis optica (NMO), in contrast to multiple sclerosis, comprises granulocyte infiltrates along extensive lengths of spinal cord, as well as optic nerve. Furthermore, IFN-β treatment worsens NMO. We recently found that experimental autoimmune encephalomyelitis (EAE) induced with
Biswajit Khatua et al.
Journal of leukocyte biology, 91(4), 641-655 (2012-01-14)
PA is an opportunistic pathogen that is commonly associated with severe infection in immunocompromised hosts. Siglec-9 binds with Sias by cis interaction on the neutrophil surface, thereby reducing immunological activity. However, neutrophils bind with pathogens through trans interactions of siglec-9
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