S7389
SB-269970 hydrochloride
powder, ≥98% (HPLC)
别名:
SB 269970A
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关于此项目
经验公式（希尔记法）:
C18H28N2O3S · HCl
化学文摘社编号:
分子量:
388.95
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D 75 to 90°, c = 1.0 in DMSO
储存条件
desiccated
溶解性
H2O: 10 mg/mL, clear (warmed to 60 °C)
储存温度
2-8°C
SMILES字符串
Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3
InChI
1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
InChI key
XQCJOYZLWFNDIO-PKLMIRHRSA-N
基因信息
human ... HTR7(3363)
应用
SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.
SB-269970 was used to study the role of 5-HT7 receptors in serotonin-induced hypothermia in rodents.6
生化/生理作用
SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT7 receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.4 SB-269970 desensitizes and decreases the excitatory effects of 5-HT7 receptors in rat hippocampus.5
Selective 5-HT7 serotonin receptor antagonist.
法律信息
Sold with the permission of GlaxoSmithKline Pharmaceuticals
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
D R Thomas et al.
British journal of pharmacology, 130(2), 409-417 (2000-05-12)
Binding of the 5-HT(7) receptor antagonist radioligand [(3)H]-SB-269970 to human 5-HT(7(a)) receptors expressed in HEK293 cell membranes (h5-HT(7(a))/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [(3)H]-5-CT binding. [(3)H]-SB-269970 (1 nM) showed full association with h5-HT(7(a))/293 membranes
Agnieszka Nikiforuk et al.
PloS one, 8(6), e66695-e66695 (2013-06-19)
A wide body of evidence suggests that 5-HT7 receptors are implicated in a variety of central nervous system functions, including control of learning and memory processes. According to recent preclinical data, the selective blockade of these receptors may be a
Krzysztof Tokarski et al.
Pharmacological reports : PR, 64(2), 256-265 (2012-06-05)
SB 269970, a 5-HT(7) receptor antagonist may produce a faster antidepressant-like effect in animal models, than do antidepressant drugs, e.g., imipramine. The present work was aimed at examining the effect of single and repeated (14 days) administration of SB 269970
Antagonism of lateral saphenous vein serotonin receptors from steers grazing endophyte-free, wild-type, or novel endophyte-infected tall fescue
Klotz JL, et al.
Journal of Animal Science, 91(9), 4492-4500 (2013)
Shun-Fan Wu et al.
Scientific reports, 5, 12247-12247 (2015-07-17)
Dopamine (DA) is a signal moiety bridging the nervous and immune systems. DA dysregulation is linked to serious human diseases, including addiction, schizophrenia, and Parkinson's disease. However, DA actions in the immune system remain incompletely understood. In this study, we
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