S7395
Spiperone
solid
别名:
8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, R 5147, Spiroperidol
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关于此项目
经验公式（希尔记法）:
C23H26FN3O2
化学文摘社编号:
分子量:
395.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
212-024-0
MDL number:
Form:
solid
form
solid
Quality Segment
color
light yellow
solubility
H2O: slightly soluble 0.2 mg/mL, 0.1 M HCl: slightly soluble 0.3 mg/mL, ethanol: 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL
SMILES string
Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4
InChI
1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
InChI key
DKGZKTPJOSAWFA-UHFFFAOYSA-N
Gene Information
General description
Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.
Application
Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor. It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.
Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.6
Biochem/physiol Actions
Selective D2 dopamine receptor antagonist; α1B-adrenoceptor antagonist; mixed 5-HT2A/5-HT1 serotonin receptor antagonist; antipsychotic.
Preparation Note
Solutions may be stored for 1-2 days at 4 °C.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges