Name: Spiperone
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₃H₂₆FN₃O₂

CAS Number:

749-02-0

分子量:

395.47

EC 号:

212-024-0

MDL编号:

MFCD00055099

UNSPSC代码:

12352200

PubChem化学物质编号:

24277908

NACRES:

NA.77

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表单

solid

质量水平

200

颜色

light yellow

溶解性

H₂O: slightly soluble 0.2 mg/mL
0.1 M HCl: slightly soluble 0.3 mg/mL
ethanol: 1.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL

SMILES字符串

Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4

InChI

1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)

InChI key

DKGZKTPJOSAWFA-UHFFFAOYSA-N

基因信息

一般描述

Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.

应用

Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor. It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.

Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.⁶