主要文件

查看所有文档

S7448

STF-62247

Name: STF-62247
Brand: SIGMA

≥98% (HPLC), solid

别名:

N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₅H₁₃N₃S

化学文摘社编号:

315702-99-9

分子量:

267.35

NACRES:

NA.77

PubChem Substance ID:

329824583

UNSPSC Code:

12352200

MDL number:

MFCD01121974

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 26 mg/mL, H₂O: insoluble

storage temp.

room temp

SMILES string

Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1

InChI

1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)

InChI key

KATNUHQNJGNLPW-UHFFFAOYSA-N

说明

Application

STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

Biochem/physiol Actions

STF-62247 is a selective inducer of autophagy in VHL-deficient renal cell carcinoma cells.

STF-62247 induces the formation of large vacuoles in the von Hippel-Lindau deficient renal carcinoma cells, a characteristic of autophagy.¹

hcodes

H413

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 4

存储类别

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.

Tomohiro Kozako et al.

BMC cancer, 18(1), 791-791 (2018-08-08)

Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis

Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death.

Sandra Turcotte et al.

Autophagy, 4(7), 944-946 (2008-09-05)

Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC

A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.

Kanchan Phadwal et al.

Autophagy, 8(4), 677-689 (2012-02-04)

Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical

查看所有相关文献

全球贸易项目编号

货号	GTIN
S7448-5MG	04061833221402