S7817
Scriptaid
synthetic (organic), ≥95%, Histone deacetylase inhibitor, solid
别名:
6-（1,3-二氧代-1H,3H-苯并[de]异喹啉-2-基）-己酸羟基酰胺
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关于此项目
经验公式（希尔记法）:
C18H18N2O4
CAS Number:
分子量:
326.35
MDL编号:
UNSPSC代码:
12352203
PubChem化学物质编号:
NACRES:
NA.77
Product Name
Scriptaid, ≥95%, solid
生物来源
synthetic (organic)
质量水平
方案
≥95%
表单
solid
mp
160-161 °C
溶解性
DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow
DMSO: 1 mg/mL
methanol: soluble
储存温度
−20°C
SMILES字符串
ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23
InChI
1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChI key
JTDYUFSDZATMKU-UHFFFAOYSA-N
相关类别
一般描述
Scriptaid 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂，可增强组蛋白的整体乙酰化。提高转录活性和蛋白表达。Scriptaid 抑制肿瘤生长。降低端粒酶活性，刺激胶质瘤细胞凋亡。
应用
Scriptaid 已被用于卵母细胞的后激活和胚胎培养。
在体细胞核移植的克隆过程中，Scriptaid 被用来增强转录活性。5,6
生化/生理作用
Scriptaid 通过诱导阻滞于 G0/G1 和/或 G2/M 期来抑制卵巢癌细胞的细胞周期进程。用 scriptaid 处理细胞会导致线粒体膜电位的丧失，H3 和组蛋白 H4 尾部的乙酰化增加。2 Sciptaid 诱导 γ 的表达-人红细胞祖细胞中的珠蛋白通过 p38 信号传导，可能是镰状细胞病的一种治疗选项。3 增强小鼠胚胎的转录活性和蛋白表达。这对生产克隆的、近交系小鼠胚胎是有用的，这些胚胎正常发育成具有正常生殖能力的成年小鼠。4
毒性低于曲古抑菌素 A 的组蛋白去乙酰化酶抑制剂；用于增强蛋白表达。
组蛋白去乙酰化酶抑制剂毒性低于曲古抑菌素 A。
特点和优势
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
法律信息
根据美国专利号 6,544,957 的许可证销售。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Nguyen Van Thuan et al.
Reproduction (Cambridge, England), 138(2), 309-317 (2009-05-13)
Since the birth of Cumulina, the first mouse clone produced by somatic cell nuclear transfer (SCNT), the success rate of cloning in mice has been extremely low compared with other species and most of the inbred mouse strains have never
Kiho Lee et al.
Molecular reproduction and development, 80(2), 145-154 (2012-12-15)
In general, pig embryos established by somatic cell nuclear transfer (SCNT) are transferred at the one-cell stage because of suboptimal embryo culture conditions. Improvements in embryo culture can increase the practical application of late embryo transfer. The goal of this
HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity
Sharma V, et al.
Journal of Cellular and Molecular Medicine, 14(8), 2151-2161 (2010)
Effects of combined treatment of MG132 and scriptaid on early and term development of porcine somatic cell nuclear transfer embryos
Mao J, et al.
Cellular Reprogramming, 14(5), 385-389 (2012)
Weihua Xu et al.
PloS one, 8(5), e64705-e64705 (2013-06-07)
Somatic cell nuclear transfer (SCNT) in mammalian cloning currently remains inefficient. Incomplete or erroneous epigenetic reprogramming of specialized donor somatic nuclear and resulting aberrant gene expression during development of cloned embryos is commonly believed as the main reason that causes
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