Merck
CN

S7817

Sigma-Aldrich

Scriptaid

≥95%, solid

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别名:
6-(1,3-二氧代-1H,3H-苯并[de]异喹啉-2-基)-己酸羟基酰胺
Empirical Formula (Hill Notation):
C18H18N2O4
分子量:
326.35
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

检测方案

≥95%

形式

solid

mp

160-161 °C

溶解性

DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow
DMSO: 1 mg/mL
methanol: soluble

储存温度

−20°C

SMILES string

ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23

InChI

1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)

InChI key

JTDYUFSDZATMKU-UHFFFAOYSA-N

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382148SML0544197345
Scriptaid ≥95%, solid

Sigma-Aldrich

S7817

Scriptaid

Sigma-Aldrich

Sigma-Aldrich

SML0544

GRI977143

BCL6 Inhibitor, 79-6 The BCL6 Inhibitor, 79-6 controls the biological activity of BCL6. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

197345

BCL6抑制剂,79-6

form

solid

form

solid

form

powder

form

powder

solubility

DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow, DMSO: 1 mg/mL, methanol: soluble

solubility

DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

一般描述

Scriptaid 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂,可增强组蛋白的整体乙酰化。提高转录活性和蛋白表达。Scriptaid 抑制肿瘤生长。降低端粒酶活性,刺激胶质瘤细胞凋亡。

应用

Scriptaid 已被用于卵母细胞的后激活和胚胎培养。
在体细胞核移植的克隆过程中,Scriptaid 被用来增强转录活性。5,6

生化/生理作用

Scriptaid 通过诱导阻滞于 G0/G1 和/或 G2/M 期来抑制卵巢癌细胞的细胞周期进程。用 scriptaid 处理细胞会导致线粒体膜电位的丧失,H3 和组蛋白 H4 尾部的乙酰化增加。2 Sciptaid 诱导 γ 的表达-人红细胞祖细胞中的珠蛋白通过 p38 信号传导,可能是镰状细胞病的一种治疗选项。3 增强小鼠胚胎的转录活性和蛋白表达。这对生产克隆的、近交系小鼠胚胎是有用的,这些胚胎正常发育成具有正常生殖能力的成年小鼠。4
毒性低于曲古抑菌素 A 的组蛋白去乙酰化酶抑制剂;用于增强蛋白表达。

特点和优势

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

法律信息

根据美国专利号 6,544,957 的许可证销售。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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其他客户在看

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Kiho Lee et al.
Molecular reproduction and development, 80(2), 145-154 (2012-12-15)
In general, pig embryos established by somatic cell nuclear transfer (SCNT) are transferred at the one-cell stage because of suboptimal embryo culture conditions. Improvements in embryo culture can increase the practical application of late embryo transfer. The goal of this
Nguyen Van Thuan et al.
Reproduction (Cambridge, England), 138(2), 309-317 (2009-05-13)
Since the birth of Cumulina, the first mouse clone produced by somatic cell nuclear transfer (SCNT), the success rate of cloning in mice has been extremely low compared with other species and most of the inbred mouse strains have never
HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity
Sharma V, et al.
Journal of Cellular and Molecular Medicine, 14(8), 2151-2161 (2010)
Noriyuki Takai et al.
International journal of molecular medicine, 17(2), 323-329 (2006-01-05)
Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest, and stimulate the apoptosis of cancer cells. We investigated the effects of a novel HDACI, Scriptaid, on the Ishikawa endometrial cancer cell line, SK-OV-3 ovarian cancer cell line
J Johnson et al.
Cellular and molecular biology (Noisy-le-Grand, France), 51(2), 229-238 (2005-09-21)
Many different classes of drugs induce fetal hemoglobin (HbF) including histone deacetylase (HDAC) inhibitors such as butyrate and trichostatin A. Although these agents induce gamma-globin expression in culture many are ineffective in vivo, therefore research efforts continue to identify clinically

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