S7821
磺胺多辛
≥95% (TLC)
别名:
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide, Sulfadoxine
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H14N4O4S
化学文摘社编号:
分子量:
310.33
UNSPSC Code:
51101500
NACRES:
NA.85
PubChem Substance ID:
EC Number:
219-504-9
Beilstein/REAXYS Number:
625453
MDL number:
InChI key
PJSFRIWCGOHTNF-UHFFFAOYSA-N
InChI
1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
SMILES string
COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC
assay
≥95% (TLC)
form
powder
color
white
solubility
ethanol: NH4OH (9:1): soluble 20 mg/mL
antibiotic activity spectrum
parasites
mode of action
enzyme | inhibits
正在寻找类似产品? 访问 产品对比指南
General description
Chemical structure: sulfonamide
Application
Sulfadoxine is a sulfonamide antibiotic used in combination with pyrimethamine for the treatment or prevention of malaria. It is also used to treat various infections in livestock. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in patients where chloroquine resistance is suspected. It is used to study infections caused by Toxoplasma gondii and has been used to prevent infections after surgery during animal studies.
Biochem/physiol Actions
Sulfadoxine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS), an enzyme that transforms 4-aminobenzoic acid (PABA) in the synthesis of dihydropteroic acid. This enzyme is also a component of the folate metabolic pathway and is upstream of dihydrofolate reductase (DHFR).
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids
Arunima Kohli et al.
Clinical epigenetics, 4(1), 17-17 (2012-09-27)
Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined the association between SHS and AAP with DNA methylation
Christine Hamann et al.
American journal of physiology. Endocrinology and metabolism, 301(6), E1220-E1228 (2011-09-09)
Patients with diabetes mellitus have an impaired bone metabolism; however, the underlying mechanisms are poorly understood. Here, we analyzed the impact of type 2 diabetes mellitus on bone physiology and regeneration using Zucker diabetic fatty (ZDF) rats, an established rat
Jae Jun Lee et al.
Korean journal of pathology, 46(6), 554-561 (2013-01-17)
The p16(INK4a) gene methylation has been reported to be a major tumorigenic mechanism. We evaluated the methylation status of the p16(INK4a) genes in 231 invasive breast cancer and 90 intraductal carcinoma specimens using a methylation-specific polymerase chain reaction and p16
Yonghui Zhang et al.
International journal of clinical and experimental pathology, 8(8), 9500-9505 (2015-10-16)
To explore the methylation status of DNA-binding inhibitor 4 (ID4) in tamoxifen-refractory (TR) breast cancer. From January 2012 to December 2014, breast cancer patients managed by radical mastectomy previously and receiving tamoxifen treatment for at least 12 months were enrolled.
H G Fischer et al.
Journal of immunology (Baltimore, Md. : 1950), 164(9), 4826-4834 (2000-04-26)
During chronic infection of mice with Toxoplasma gondii, gene message for IL-12p40, CD86, and the potassium channel Kv1.3 was detected in brain mononuclear cells, suggesting the presence of dendritic cells (DC) in the CNS. Consistently, cells bearing the DC markers
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持