S7826
SMER3
≥98% (HPLC)
别名:
9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one
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关于此项目
经验公式（希尔记法）:
C11H4N4O2
化学文摘社编号:
分子量:
224.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
SFSSAKVWCKFRHE-UHFFFAOYSA-N
SMILES string
O=C1c2ccccc2-c3nc4nonc4nc13
InChI
1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥30 mg/mL
storage temp.
2-8°C
Quality Level
Application
SMER3 may be used in cell signaling studies.
Biochem/physiol Actions
Inhibition of SCFMet30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.1
Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Mariam Aghajan et al.
Nature biotechnology, 28(7), 738-742 (2010-06-29)
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pathway inhibition are needed. We used a yeast-based screen to
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