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S7936

SB 205384

solid

别名:

4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester

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关于此项目

经验公式（希尔记法）:
C17H18N2O3S
化学文摘社编号:
160296-13-9
分子量:
330.40
NACRES:
NA.77
PubChem Substance ID:
24278711
UNSPSC Code:
12352200
MDL number:
MFCD00918851
Form:
solid
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form

solid

color

off-white

solubility

DMSO: 18 mg/mL, H2O: insoluble

SMILES string

CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N

InChI

1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19)

InChI key

JDTZAGLGBRRCJT-UHFFFAOYSA-N

Application

SB 205384 was used to study GABA-gated currents in rat locus coeruleus neurons.6

Biochem/physiol Actions

GABAA receptor modulator selective for the α3β2γ2 subunit combination.
SB 205384 is a selective and positive allosteric modulator of non-benzodiazepine site of the GABAA receptor.3 It affects the extrasynaptic GABAA receptors in rat cortical neurons4 and enhances the GABAergic transmission onto pro-opiomelanocortin neurons in mice.5

Legal Information

Manufactured and sold under license from GlaxoSmithKline Pharmaceuticals

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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