S7947
Stattic
≥98% (HPLC), STAT3 activation inhibitor, powder
别名:
6-硝基苯并[b] 噻吩-1,1-二氧化物, Stat 三种抑制化合物
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C8H5NO4S
化学文摘社编号:
分子量:
211.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Stattic, ≥98% (HPLC), powder
SMILES string
[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
InChI key
ZRRGOUHITGRLBA-UHFFFAOYSA-N
InChI
1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >20 mg/mL
Quality Level
Application
Stattic 用于抑制信号转导子和转录激活因子3（STAT3）的活性，适用各种细胞系和培养物中。
Stattic 用于研究人肺癌细胞中 Stat3 介导的细胞信号传导。5
Biochem/physiol Actions
Stattic 是一种不可逆的 STAT3 活化抑制剂。
Stattic（Stat3 三抑制化合物）改变 Stat3 的 SH2 结构域，间接抑制与磷肽结合。与其他磷酸肽类相比，它易于跨膜转运。2 Stattic 诱导 ROS 形成增加，对心肌细胞线粒体功能产生负面影响， 3 并使鼻咽癌细胞对放化疗敏感。4
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Human dental pulp stem cells grown in neurogenic media differentiate into endothelial cells and promote neovasculogenesis in the mouse brain.
Luzuriaga J, et al.
Frontiers in Physiology, 10, 347-347 (2019)
Long noncoding RNA PVT1 promotes hepatoblastoma cell proliferation through activating STAT3
Luo Z and Cao P
Cancer Management and Research, 11, 8517-8517 (2019)
Matthew A Bill et al.
Molecular cancer, 9, 165-165 (2010-06-26)
We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells. FLLL32
Yunbao Pan et al.
PloS one, 8(1), e54565-e54565 (2013-02-06)
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia, Africa and Alaska. Radiotherapy and cisplatin-based chemotherapy are the main treatment options. Unfortunately, disease response to concurrent chemoradiotherapy varies among patients with NPC, and many cases are
Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway
Cheng M, et al.
American Journal of Translational Research, 11(4), 2317-2317 (2019)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持