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S8139

舒林酸

≥98.0%

别名:

(Z)-5-氟-2-甲基-1-[4-(甲亚硫酰苯基)亚甲基]-1H-茚-3-醋酸

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关于此项目

经验公式（希尔记法）:
C20H17FO3S
化学文摘社编号:
38194-50-2
分子量:
356.41
NACRES:
NA.77
PubChem Substance ID:
57654635
UNSPSC Code:
12161501
EC Number:
253-819-2
MDL number:
MFCD00599589
Assay:
≥98.0%
Form:
powder
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biological source

synthetic (organic)

assay

≥98.0%

form

powder

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

solubility

methanol: 50 mg/mL

application(s)

forensics and toxicology
veterinary

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O

InChI

1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key

MLKXDPUZXIRXEP-MFOYZWKCSA-N

Gene Information

human ... ALB(213), PTGS1(5742), PTGS2(5743)

Application

处理人结肠癌细胞系可诱导 MRP1 和 MRP3，但不会诱导 MRP 家族的其他成员。据报道，可显着增加蒽环类药物（阿霉素、柔红霉素和表柔比星）以及替尼泊苷、VP-16 和长春新碱的细胞毒性。测试了舒林酸在体外对热诱导白蛋白变性的影响28，以及其与人血浆蛋白结合的能力。29

Biochem/physiol Actions

舒林酸是非甾体抗炎药，是具有抗增殖和凋亡作用的镇痛药。它抑制人结肠癌细胞中环氧合酶 2 的表达和活性25,26，并减轻腺瘤性息肉病患者的肿瘤负担。27
非甾体抗炎药；COX-1 的选择性抑制剂。

Features and Benefits

该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCK5833
MKCH7987
MKCD9343
MKBZ4918V
MKBV4618V

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