S8197
SMER28
>99% (HPLC), solid
别名:
6-bromo-N-2-propenyl-4-quinazolinamine
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关于此项目
经验公式（希尔记法）:
C11H10BrN3
化学文摘社编号:
分子量:
264.12
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
>99% (HPLC)
Form:
solid
Quality Segment
assay
>99% (HPLC)
form
solid
solubility
DMSO: >20 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
Brc1ccc2ncnc(NCC=C)c2c1
InChI
1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
InChI key
BCPOLXUSCUFDGE-UHFFFAOYSA-N
Application
SMER28 may be used in mTOR-mediated signaling studies.
Biochem/physiol Actions
SMER28 is a small molecule modulator of mammalian autophagy.
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.
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存储类别
11 - Combustible Solids
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