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S8197

SMER28

Name: SMER28
Brand: SIGMA

>99% (HPLC), solid

别名:

6-bromo-N-2-propenyl-4-quinazolinamine

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关于此项目

经验公式（希尔记法）:

C₁₁H₁₀BrN₃

化学文摘社编号:

307538-42-7

分子量:

264.12

NACRES:

NA.77

PubChem Substance ID:

329824598

UNSPSC Code:

12352200

MDL number:

MFCD02166825

Assay:

>99% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

>99% (HPLC)

form

solid

solubility

DMSO: >20 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Brc1ccc2ncnc(NCC=C)c2c1

InChI

1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

InChI key

BCPOLXUSCUFDGE-UHFFFAOYSA-N

说明

Application

SMER28 may be used in mTOR-mediated signaling studies.

Biochem/physiol Actions

SMER28 is a small molecule modulator of mammalian autophagy.

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

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存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

0000523486

0000163954

0000104606

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Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.

Ann K Rosenthal et al.

The Journal of biological chemistry, 290(21), 13028-13038 (2015-04-15)

Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain poorly characterized; although in some cell types, the generation of extracellular vesicles is associated

Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.

Dee Shen et al.

Cell biochemistry and biophysics, 60(3), 173-185 (2010-12-07)

Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and

A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast.

Prashant Bharadwaj et al.

Neural regeneration research, 15(10), 1931-1936 (2020-04-05)

Multiple lines of evidence show that soluble oligomer forms of amyloid β protein (Aβ42) are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer's disease. Although many studies have

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全球贸易项目编号

货号	GTIN
S8197-25MG	04061832982229
S8197-5MG	04061832982236