S8326
SKI 5C
≥98% (HPLC)
别名:
2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethyl ester-3-oxazolidinecarboxylic acid, SPHK1 Inhibitor 5C
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关于此项目
经验公式（希尔记法）:
C26H45NO4
化学文摘社编号:
分子量:
435.64
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
oil
color
colorless to light brown
storage temp.
2-8°C
SMILES string
CCCCCCCCCCCCCC#CC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C
InChI
1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1
InChI key
YGBSGZPIDCXNEH-QFIPXVFZSA-N
Application
SKI 5C was used to inhibit Sphingosine kinase 1 in SK-Hep1, HEK-293T cells.1
Biochem/physiol Actions
SKI 5C is a selective Sphingosine Kinase 1 (SPHK1) inhibitor.
SKI 5C is a sphingosine kinase 1 inhibitor.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Youmna Atieh et al.
Current biology : CB, 31(6), 1129-1140 (2021-01-06)
Extrusion is a mechanism used to eliminate unfit, excess, or dying cells from epithelial tissues. The initial events guiding which cells will be selectively extruded from the epithelium are not well understood. Here, we induced damage in a subset of
Meiyan Bao et al.
Liver international : official journal of the International Association for the Study of the Liver, 32(2), 331-338 (2011-11-22)
Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine-1-phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene in tumorigenesis. However, little is known about the precise role of the SphK1/S1P pathway in human liver
Sebastian Wurster et al.
Cell reports, 34(12), 108896-108896 (2021-03-25)
Severe and often fatal opportunistic fungal infections arise frequently following mucosal damage caused by trauma or cytotoxic chemotherapy. Interaction of fungal pathogens with epithelial cells that comprise mucosae is a key early event associated with invasion, and, therefore, enhancing epithelial
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S8326-5MG | 04061832449807 |
| S8326-25MG | 04061832449791 |