(−)-Scopolamine methyl bromide

Name: (−)-Scopolamine methyl bromide
Brand: SIGMA

≥98% (HPLC), powder

别名:

Hyoscine methyl bromide, Methscopolamine bromide

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所有图片(3)

About This Item

经验公式（希尔记法）:

C₁₈H₂₄NO₄ · Br

CAS Number:

155-41-9

分子量:

398.29

EC 号:

205-844-5

MDL编号:

MFCD00078560

UNSPSC代码:

12352116

PubChem化学物质编号:

24278714

NACRES:

NA.77

质量水平

200

方案

≥98% (HPLC)

表单

powder

旋光性

[α]25/D −25°, c = 5 in H₂O(lit.)

颜色

white

溶解性

H₂O: 50 mg/mL

SMILES字符串

[Br-].[H][C@]12C[C@@H](C[C@]([H])([C@@]3([H])O[C@@]13[H])[N+]2(C)C)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1

InChI key

CXYRUNPLKGGUJF-RAFJPFSSSA-M

基因信息

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

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应用

(−)-Scopolamine methyl bromide was administered to rats to inhibit the peripheral cholinergic effects induced by pilocarpine.^10,11

生化/生理作用

Competitive muscarinic acetylcholine receptor antagonist.

Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.⁷ The central effects include hallucinations, disorientation, restlessness and euphoria.⁸ Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.⁹