S8572
Anti-STIM2 兔抗
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-stromal interaction molecule 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
18
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~100 kDa
species reactivity
human, mouse, rat
concentration
~1.0 mg/mL
technique(s)
western blot: 0.1-0.2 μg/mL using whole extract of mouse brain, western blot: 0.5-1.0 μg/mL using rat brain, western blot: 0.5-1.0 μg/mL using whole extracts of human U87 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... STIM2(57620)
mouse ... Stim2(116873)
rat ... Stim2(117087)
General description
STIM (stromal interaction molecule) proteins are conserved single-pass transmembrane protein. The three STIM proteins, STIM1, STIM2 and D-Stim, are ubiquitously expressed proteins composed of a single SAM (sterile α-motif) domain and an unpaired EF hand within the highly conserved extracellular region and coiled-coil domains that are conserved in structure and position within the cytoplasmic region. Significant divergence between these proteins was found only at the extreme C-termini. STIM proteins are modified by phosphorylation and N-linked glycosylation.
Immunogen
synthetic peptide corresponding to amino acids 812-833 of human STIM2, conjugated to KLH. The corresponding sequence is identical in rat and mouse.
Application
Anti-STIM2 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
STIM (stromal interaction molecule) required for the regulation of store-operated Ca2+ influx. Store-operated calcium entry is mediated by Ca2+ release-activated Ca2+ (CRAC) channels, following Ca2+ depletion from the endoplasmic reticulum (ER) stores. This process is crucial for gene transcription, proliferation and cytokine release. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ entry. STIM2 co-localizes with STIM1 in punctae upon store depletion, and coprecipitates with STIM1 from cell lysates, suggesting that they may play a coordinated role in controlling Ca2+ entry.
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine bv2 microglia cells: early cellular responses to ATP-mediated microglia activation
Gilbert DF, et al.
Frontiers in Molecular Neuroscience, 9, 111-111 (2016)
A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels
Saul S, et al.
Science Signaling, 9(418), ra26-ra26 (2016)
Inverse regulation of melanoma growth and migration by O rai1/STIM 2-dependent calcium entry
Stanisz H, et al.
Pigment Cell & Melanoma Research, 27(3), 442-453 (2014)
Familial Alzheimer?s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis
Greotti E, et al.
Cell Calcium, 79(14), 44-56 (2019)
Biochemical properties and cellular localisation of STIM proteins
Dziadek MA and Johnstone LS
Cell Calcium, 42(2), 123-132 (2007)
相关内容
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